p63基因及其在宫颈癌中的研究进展  

Research Progress of p63 Gene and Its Role in Cervical Cancer

作　　者：薛秀秀 沙仁高娃[1] 

机构地区：[1]青海大学附属医院,青海 西宁

出　　处：《临床医学进展》2022年第4期3265-3271,共7页Advances in Clinical Medicine

摘　　要：转录因子p63是p53家族成员之一,在调节母体生殖和基因组完整性以及表皮发育、增殖潜能、分化、细胞死亡和存活中起重要作用。在女性生殖系统中,宫颈癌严重威胁着妇女的生命健康。现有研究认为细胞的癌变是抑癌基因和癌基因之间功能失衡所致。p63在宫颈癌组织及癌旁组织的差异表达,表明其在宫颈癌中具有非同寻常的作用。如今,p63在癌症中的作用存在很大争议。为此,本文就p63基因、结构与功能及其与宫颈癌的相互作用关系研究进展作一综述。Transcription factor p63, a member of the p53 family, plays an important role in regulating ma-ternal reproduction and genome integrity as well as epidermal development, proliferation potential, differentiation, cell death and survival. In female reproductive system, cervical cancer is a serious threat to women’s life and health. Current studies suggest that the canceration of cells is caused by the dysfunction between tumor suppressor genes and oncogenes. The differential expression of p63 in cervical and paracancer tissues indicated that p63 plays an extraordinary role in cervical cancer. Today, the role of p63 in cancer is highly controversial. In this review, the structure and function of p63 gene and its interaction with cervical cancer were reviewed.

关 键 词：P63 宫颈癌 HPV E6 HPV E7 CIN 

分 类 号：R737.33[医药卫生—肿瘤]