长链非编码RNA TINCR在肿瘤中的作用研究进展  

Research Progress of Long Non-Coding RNA TINCR Involved in Tumor

作　　者：郑欣 罗烨[1] 

机构地区：[1]衢州职业技术学院医学院,浙江 衢州

出　　处：《临床医学进展》2022年第5期4632-4637,共6页Advances in Clinical Medicine

摘　　要：随着高通量测序技术的发展,一类转录本长度大于200 nt的RNA分子——长链非编码RNA (long non-coding RNA, lncRNA),成为了肿瘤领域的研究热点。研究表明,lncRNA在诸多肿瘤的发生发展过程中均发挥着十分重要的作用。组织分化诱导非蛋白编码RNA (Terminal differentiation-induced non-coding RNA, TINCR)在表皮细胞分化过程中至关重要。近年来研究发现,TINCR在肝细胞癌、乳腺癌、肺癌、前列腺癌、膀胱癌等多种恶性肿瘤中表达异常,且能通过不同机制影响肿瘤进程。TINCR有望成为肿瘤早期诊断、治疗及预后的分子靶标。With the development of high-throughput sequencing technology, lncRNA, whose transcripts are longer than 200 nt, has become the research hotspots in tumorigenesis. Research shows that lncRNA plays a key role in the occurrence and development of numerous tumors. Terminal differ-entiation-induced non-coding RNA (TINCR) was found to control human epidermal differentiation. Recently, TINCR has been found to have aberrant expression in multiple malignant tumors such as hepatocellular carcinoma, breast cancer, lung cancer, prostate cancer and bladder cancer, and be involved in tumorigenesis through different mechanism. TINCR are expected to be a new molecular target for early diagnosis, treatment and prognosis of malignant tumors.

关 键 词：长链非编码RNA 组织分化诱导非蛋白编码RNA (TINCR) 肿瘤 

分 类 号：R73[医药卫生—肿瘤]