生酮饮食抗癫痫治疗的机制研究进展  

Research Progress on the Mechanism of Ketogenic Diet in Antiepilepsy

作　　者：王贞芸 王兰桂[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院,青海 西宁

出　　处：《临床医学进展》2022年第6期5849-5855,共7页Advances in Clinical Medicine

摘　　要：癫痫是慢性神经系统疾病,对患者的神经功能造成严重损害,目前抗癫痫主要包括药物及手术治疗,但部分难治性癫痫患者经手术治疗或两种以上抗癫痫药物治疗后仍然无法有效控制癫痫发作,目前国外提倡用生酮饮食治疗难治性癫痫,并且取得了良好的临床效果,在1998年对51名患有耐药性癫痫的儿童进行的一项多中心研究显示坚持生酮饮食一年的患儿中43%无癫痫发作,39%控制了50%~90%的癫痫发作,但生酮饮食抗癫痫治疗的机制尚不完全明确,本文就生酮饮食抗癫痫治疗机制的目前的研究进展进行综述。Epilepsy is a chronic nervous system disease, which causes serious damage to the neurological function of patients. At present, antiepileptic drug treatment and surgical treatment are the main treatment options, but some patients with refractory epilepsy still can not control epilepsy after surgical treatment or more than two kinds of antiepileptic drugs. At present, ketogenic diet is ad-vocated in foreign countries, and good clinical results have been achieved, a multi center study of 51 children with drug-resistant epilepsy in 1998 showed that 43% of the children who insisted on ke-togenic diet for one year had no seizures, and 39% controlled 50%~90% of the seizures. However, the mechanism of ketogenic diet antiepileptic therapy is not completely clear. This paper reviews the current research progress on the mechanism of ketogenic diet antiepileptic therapy.

关 键 词：生酮饮食 癫痫 研究进展 

分 类 号：R742.1[医药卫生—神经病学与精神病学]