那他霉素及其衍生物在眼部感染性疾病中的应用与研究进展  

Application and Research Progress of Natamycin and Its Derivatives in Ocular Infectious Diseases

作　　者：纪晓月 田雪 彭旭东[2] 

机构地区：[1]青岛大学,山东 青岛 [2]青岛大学附属医院,山东 青岛

出　　处：《临床医学进展》2022年第6期5863-5869,共7页Advances in Clinical Medicine

摘　　要：那他霉素作为一种广谱抗真菌的多烯大环内酯类抗生素,在临床上被广泛用于治疗眼部浅表真菌感染,也应用于农业和食品防腐等领域。但随着长期使用,那他霉素也表现出眼部低渗透性、耐药性等缺点。本文主要以近年来国内外研究报道的那他霉素及其衍生物的文献为基础,对其药理作用和机制,以及在眼部感染性疾病中的应用进行总结,以期为那他霉素的深入研究和开发利用提供参考。Natamycin, as a broad-spectrum antifungal polyene macrolide antibiotic, is widely used in clinical treatment of superficial fungal infections of the eye, and also in the fields of agriculture and food preservation. However, with long-term use, natamycin also shows shortcomings such as low ocular permeability and drug resistance. This article is mainly based on the literature of natamycin and its derivatives reported in recent years at home and abroad, and summarizes its pharmacological ac-tion and mechanism, as well as its application in ocular infectious diseases, providing reference for in-depth research and development and utilization.

关 键 词：那他霉素 药理研究 真菌性角膜炎 临床应用 

分 类 号：R771.3[医药卫生—眼科]