常染色体显性遗传性多囊肾的中西医诊疗研究进展  

Progress in the Diagnosis and Treatment of Traditional Chinese Medicine and Western Medicine for Autosomal Dominant Polycystic Kidney Disease

作　　者：杜艾琳 李芳[2] 卢子怡 

机构地区：[1]黑龙江中医药大学,黑龙江 哈尔滨 [2]中国人民解放军联勤保障部队第962医院,肾内科,黑龙江 哈尔滨

出　　处：《临床医学进展》2022年第9期8487-8492,共6页Advances in Clinical Medicine

摘　　要：常染色体显性遗传性多囊肾病(autosomal dominant polycystic kidney disease, ADPKD)是一种常见的遗传性肾脏疾病,主要表现为肾脏表面及内部多发囊肿的形成,导致肾脏功能进行性下降。该病的发病率日趋上升,但目前治疗上多为对症治疗,仅有托伐普坦一种针对病因治疗的药物被批准使用。近年来,随着发病机制的明确,更多的治疗靶点投入研究。本文从中西医两方面系统综述了ADPKD一般诊疗的进展,展望更多针对病因治疗的药物研究前景,旨在提高人们对该疾病的认识,为临床诊疗提供更多思路。Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney dis-ease, mainly manifested as the formation of multiple cysts on the surface and inside the kidney, leading to a progressive decline in kidney function. The incidence of the disease is increasing, but the current treatment is mostly symptomatic treatment, only tolvaptan that is a drug for etiological treatment is approved for use. Moreover, in recent years, with the clear pathogenesis, more thera-peutic targets have been put into research. This paper systematically reviews the progress of gen-eral diagnosis and treatment of ADPKD from traditional Chinese and western medicine, and looks forward to more drug research prospects for the etiology and treatment, aiming to improve people’s understanding of the disease and provide more ideas for clinical diagnosis and treatment.

关 键 词：常染色体显性遗传性多囊肾病 囊肿 西医诊疗 中医诊疗 

分 类 号：R692[医药卫生—泌尿科学]