脱矿牙本质基质作为rhBMP-2载体的研究进展  

Research Progress of Demineralized Dentin Matrix as rhBMP-2 Carrier

作　　者：张迪 达尔亚·俄尼木拜 古丽努尔·阿吾提[1,2] 

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)牙周病科,新疆 乌鲁木齐 [2]新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐

出　　处：《临床医学进展》2022年第10期9456-9460,共5页Advances in Clinical Medicine

摘　　要：骨形态发生蛋白-2 (bone morphogentic protein-2, BMP-2)是转化生长因子-β家族的成员,可促进骨髓间充质干细胞分化为成骨细胞和软骨细胞。脱矿牙本质基质(demineralized dentin matrix, DDM)是由牙本质经过粉碎、脱矿、灭菌等处理后制得,具有良好的骨诱导性、骨传导性和生物相容性等特性,是一种颇有前景的骨移植材料。DDM不仅是一种骨移植材料,也可作为重组人骨形态发生蛋白-2 (recombinant human bone morphogentic protein-2, rhBMP-2)的合适载体。DDM与rhBMP-2有着较好的亲和力,并能够缓释rhBMP-2。此外,外源性的rhBMP-2和DDM中内源性BMP具有协同效应,可产生更多的新骨。DDM用作rhBMP-2载体时,rhBMP-2的浓度可降低为0.2 mg/mL。Bone morphogenetic protein-2 (BMP-2) is a transforming growth factor-β family member. It can promote bone marrow mesenchymal stem cells to differentiate into osteoblasts and chondrocytes. Demineralized dentin matrix (DDM) is prepared from dentin after grinding, demineralization, steri-lization, etc. It has good osteoinductive, osteoconductive, biocompatibility, and is a promising bone graft material. DDM is not only a bone graft material, but also a suitable carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2). DDM has good affinity with rhBMP-2 and can slowly release rhBMP-2. In addition, exogenous rhBMP-2 and endogenous BMP in DDM have syner-gistic effects, which can produce more new bones. When DDM is used as rhBMP-2 carrier, the con-centration of rhBMP-2 can be reduced to 0.2 mg/mL.

关 键 词：脱矿牙本质基质 骨移植材料 骨诱导 骨传导 重组人骨形态发生蛋白-2 

分 类 号：R783.1[医药卫生—口腔医学]