结直肠腺瘤癌变的发生机制及相关危险因素研究进展  

Research Status of the Mechanism and Related Risk Factors of Colorectal Adenoma Carcinogenesis

作　　者：杜文涛 许雅洁 姜相君[2] 

机构地区：[1]潍坊医学院临床医学院,山东 潍坊 [2]青岛市市立医院消化内科,山东 青岛

出　　处：《临床医学进展》2022年第11期10067-10074,共8页Advances in Clinical Medicine

摘　　要：结直肠癌是消化系统最常见的恶性肿瘤之一,在全球范围内发病率逐年上升,病死率高,预后较差。结直肠腺瘤作为结直肠癌重要的癌前病变,可经过多种复杂的机制发生癌变,最终演变为结直肠癌。本文总结近年来结直肠腺瘤癌变的发生机制、相关危险因素及研究进展,从多种途径出发,为结直肠癌及其癌前病变的研究提供理论依据,以更好的指导临床诊断与治疗。Colorectal cancer is one of the most common malignant tumors of the gastrointestinal system, and its incidence is increasing year by year worldwide, with high mortality rate and poor prognosis. Colorectal adenoma is an important precancerous lesion of colorectal cancer, which can develop into colorectal cancer in many ways, involving multiple mechanisms and complex processes. This paper summarized the mechanism of colorectal adenoma carcinogenesis, related risk factors and research progress in recent years, and provided a theoretical basis for the study of colorectal cancer and its precancerous lesions from multiple pathways, so as to better guide clinical diagnosis and treatment.

关 键 词：结直肠腺瘤 癌变 发生机制 危险因素 

分 类 号：R73[医药卫生—肿瘤]