外泌体对于缺血性脑卒中的保护作用机制研究进展  

Progress in the Mechanism of the Protective Effect of Exosomes on Ischemic Stroke

作　　者：饶静 辛亮 魏亚囡 张禄露 徐瑞芬[2] 

机构地区：[1]西安医学院,陕西 西安 [2]陕西省人民医院,陕西 西安

出　　处：《临床医学进展》2022年第11期10591-10597,共7页Advances in Clinical Medicine

摘　　要：外泌体作为近些年来发现的一种由体内多种细胞分泌的纳米级细胞外囊泡(EV),可携带蛋白质、脂质、miRNA等分子物质参与细胞间的信息传递,靶向调控基因表达,并与生物体内多系统器官疾病的发展及预后密切相关。研究发现,外泌体在缺血性脑卒中的发病及预后均发挥了重要作用。并且基于其独特的性质,外泌体作为一种极具前景的药物递送载体引起了越来越多的关注。本文综述了外泌体在缺血性脑卒中的保护领域的最新研究进展。Exosomes, as a kind of nanoscale extracellular vesicles (EVs) secreted by various cells in the body discovered in recent years, can carry proteins, lipids, miRNAs, and other molecular substances to participate in intercellular information transfer, targeting and regulating gene expression, and are closely related to the development and prognosis of multi-system organ diseases in living organ-isms. It has been found that exosomes play an important role in both the pathogenesis and progno-sis of ischemic stroke. And based on their unique properties, exosomes have attracted increasing attention as a promising drug delivery vehicle. In this paper, we review the latest research progress in the field of exosome protection in ischemic stroke.

关 键 词：外泌体 缺血性脑卒中 微小核糖核酸 

分 类 号：R74[医药卫生—神经病学与精神病学]