中脑多巴胺能神经元调节中枢神经系统的研究进展  

Research Progress on the Regulation of the Central Nervous System by Dopaminergic Neurons in the Midbrain

作　　者：何娟 阳小飞[1] 

机构地区：[1]中南民族大学生物医学工程学院,湖北 武汉

出　　处：《临床医学进展》2022年第11期10742-10747,共6页Advances in Clinical Medicine

摘　　要：中枢神经系统中,中脑多巴胺能系统作为多巴胺能神经元的主要聚集地,其释放的单胺类神经递质多巴胺已被广泛研究,其中多巴胺的异常释放会导致成瘾行为以及某些神经系统疾病的产生。本篇综述着重于叙述中脑多巴胺能系统的相关研究进展,包括多巴胺及受体、多巴胺的电生理特性、腹侧被盖区、黑质致密部四个部分。这为中脑多巴胺能系统对于整个中枢神经系统中神经疾病的研究提供了参考资料。In the central nervous system, the midbrain dopaminergic system as the main aggregation of do-paminergic neurons, its release of the excitatory neurotransmitter dopamine has been extensively studied, where abnormal release of dopamine can lead to addictive behaviors as well as the pro-duction of certain neurological diseases. This review focuses on the research progress of the do-paminergic system of the midbrain, including dopamine and receptors, electrophysiological proper-ties of dopamine, ventral tegmental area, and substantia nigra. The midbrain dopaminergic system is crucial for the study of neurological diseases throughout the central nervous system, and is the significance of this review.

关 键 词：中脑多巴胺能系统 多巴胺 腹侧被盖区 黑质致密部 中枢神经系统疾病 

分 类 号：R74[医药卫生—神经病学与精神病学]