铁调节蛋白1 (IRP1/ACO1)在疾病中的作用机制  

Mechanism Action of Iron Regulatory Protein 1 (IRP1/ACO1) in Disease

作　　者：闫妠 张莹莹 亓同钢[1] 

机构地区：[1]山东大学第二医院基础医学研究所,山东 济南

出　　处：《临床医学进展》2022年第12期11662-11668,共7页Advances in Clinical Medicine

摘　　要：铁调节蛋白1 (IRP1/ACO1)是存在于细胞质中的双功能蛋白质,主要通过铁–硫开关机制来反应细胞溶质铁状态,在具有连接到其活性位点的铁–硫簇的活性细胞溶质乌头酸酶形式和结合铁反应元件的脱辅基蛋白形式之间交替,但不存在量的变化。相关研究表明铁调节蛋白1 (IRP1/ACO1)通过调控低氧诱导因子2α以及铁下垂等过程在多种疾病的发生发展进程中发挥重要作用。本文着重介绍了IRP1在肿瘤、神经退行性疾病、血液系统疾病中的作用,最后总结IRP1在医学中的潜在应用价值及未来前景。Iron regulatory protein 1 (IRP1/ACO1) is a bifunctional protein present in the cytoplasm that re-sponds to cytosolic iron status mainly through an iron-sulfur switching mechanism, alternating between an active cytosolic ubiquinone form with an iron-sulfur cluster attached to its active site and a decofactorized protein form that binds iron-responsive elements, but without quantitative changes. Related studies have shown that iron regulatory protein 1 (IRP1/ACO1) plays an im-portant role in the developmental process of several diseases by regulating processes such as hy-poxia-inducible factor 2α as well as iron sagging. This paper highlights the role of IRP1 in tumors, neurodegenerative diseases, and hematological disorders, and finally summarizes the potential applications of IRP1 in medicine and its future prospects.

关 键 词：铁调节蛋白1 (IRP1/ACO1) 铁下垂 低氧诱导因子2α (HIF-2α) 癌基因成瘾 

分 类 号：R73[医药卫生—肿瘤]