信号素3F在神经系统中的作用及其机制研究进展  

Research Progress on the Role of Semaphorin3F in Nervous System and Its Mechanism

作　　者：潘浩 杨晓帆 杨光路 

机构地区：[1]内蒙古医科大学,内蒙古 呼和浩特

出　　处：《临床医学进展》2022年第12期11770-11779,共10页Advances in Clinical Medicine

摘　　要：信号素3F是第三类信号素家族的信号蛋白,最初作为轴突发育的引导分子被发现。在神经系统发育过程中,信号素3F作为配体通过其全受体复合物在神经元产生增殖到神经网络的形成与功能维持等诸多步骤。信号素3F缺失会造成发育过程中的神经系统轴突异常延伸,突触可塑性受限等发育异常,造成神经系统兴奋性与抑制性失衡。信号素3F在癫痫、孤独症谱系障碍、恶性肿瘤发生中的作用被识别。在本综述中主要讨论了信号素3F如何通过其全受体复合物发挥作用,以及信号素3F在神经系统中的生理和病理中的功能。Semaphorin3F is a signaling protein of the third type of signaling element family, and was initially found as a leader molecule for axonal development. In the process of nervous system development, Semaphorin3F, as a ligand, can proliferate in neurons to form a neural network and maintain its function through its whole receptor complex. The absence of Semaphorin3F may cause develop-mental abnormalities such as abnormal axonal extension of the nervous system and limited syn-aptic plasticity in the development process, resulting in an imbalance between excitability and in-hibitory activity in the nervous system. The role of Semaphorin3F in the development of epilepsy, autism spectrum disorder and malignant tumor has been recognized. In this review, we mainly discuss how Semaphorin3F works through its full receptor complex, and the physiological and pathological functions of Semaphorin3F in the nervous system.

关 键 词：信号素3F 神经毡蛋白-2 神经丛蛋白 信号转导 神经网络发育 癫痫 

分 类 号：R74[医药卫生—神经病学与精神病学]