光动力疗法联合PD-1抑制剂治疗支气管肿瘤1例并文献复习  

A Case of Elderly Refractory Giant Stone Bile Duct Stent Combined with Pharmacological Treatment and Review of Literature

作　　者：王靖宇 曹艺巍[2] 韩伟忠[2] 林存智[2] 

机构地区：[1]青岛大学,山东 青岛 [2]青岛大学附属医院,山东 青岛

出　　处：《临床医学进展》2023年第2期2136-2141,共6页Advances in Clinical Medicine

摘　　要：最近的实验研究发现,光动力疗法(PDT)联合程序性死亡受体1 (PD-1)/程序性细胞死亡配体1 (PD-L1)抑制剂可以有效抑制原位肿瘤生长,防止肿瘤复发和转移,已成为一种新的治疗方案。然而,临床数据仍然有限。在此,我们介绍了一例晚期肺癌患者在PDT联合PD-1抑制剂治疗后获得完全缓解(CR),并在14个月的随访中没有复发和转移的病例报告。通过这种方式,我们回顾了PDT联合PD-1/PD-L1抑制剂的文献,并对实验和临床数据以及可能的分子机制进行了概述。Recent experimental studies have found that photodynamic therapy (PDT) combined with pro-grammed death receptor 1 (PD-1)/programmed cell death-Ligand 1 (PD-L1) inhibitors can effec-tively inhibit in situ tumor growth and prevent tumor recurrence and metastasis, and has emerged as a new therapeutic option. However, clinical data is still limited. Here, we present a case report of a patient with advanced lung cancer who achieved complete remission (CR) after PDT combined with a PD-1 inhibitor and was free of recurrence and metastasis during 14 months of follow-up. In this way, we review the literature on PDT in combination with PD-1/PD-L1 inhibitors and provide an overview of the experimental and clinical data and possible molecular mechanisms.

关 键 词：光动力疗法 程序性死亡受体1 支气管肿瘤 基于纳米技术的光动力免疫疗法 免疫检查点抑制剂 

分 类 号：R73[医药卫生—肿瘤]