高血压脑出血相关炎症反应的最新研究进展  

The Latest Research Progress of Inflammatory Response Related to Hypertensive Intracerebral Hemorrhage

作　　者：王婷 孙斌[2] 何宗钊[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海省人民医院重症医学科,青海 西宁

出　　处：《临床医学进展》2023年第2期2522-2528,共7页Advances in Clinical Medicine

摘　　要：高血压是脑出血最常见的原因,高血压脑出血具有高致死率和高致残率。过去人们对高血压脑出血的发生机制已经有了很多的了解,如今,我们认识到,NLRP3炎性体在脑出血后被激活,导致级联反应加重颅脑损伤。一些炎症指标如:白细胞、小胶质细胞、淋巴细胞、中性粒细胞、降钙素原、白介素、肿瘤坏死因子等引起的炎症反应在高血压脑出血中也发挥了重要的作用。可导致血脑屏障破坏、脑水肿等继发性脑损伤的发生。Hypertension is the most common cause of cerebral hemorrhage, and hypertensive cerebral hem-orrhage has a high mortality and disability rate. In the past, people have learned a lot about the mechanism of hypertensive intracerebral hemorrhage. We recognize that NLRP3 inflammatory body is activated after intracerebral hemorrhage, leading to cascade reaction and aggravating brain injury. Inflammatory reactions caused by some inflammatory indicators such as white blood cells, microglia, lymphocytes, neutrophils, procalcitonin, interleukin, tumor necrosis factor, etc. also play a role in hypertensive intracerebral hemorrhage, which can lead to the occurrence of secondary brain damage such as blood-brain barrier disruption and cerebral edema.

关 键 词：脑出血 高血压 炎症 脑水肿 

分 类 号：R74[医药卫生—神经病学与精神病学]