扩大的血管周围间隙与非心源性脑梗死患者缺血性卒中复发的相关性  

Correlation of Enlarged Perivascular Spaces with Recurrent Ischemic Stroke in Patients with Noncardiogenic Cerebral Infarction

作　　者：杨晓雨[1] 苏宸 王瑶[1] 赵仁亮[1] 

机构地区：[1]青岛大学附属医院神经内科,山东 青岛

出　　处：《临床医学进展》2023年第3期3723-3730,共8页Advances in Clinical Medicine

摘　　要：目的:探讨不同部位的扩大的血管周围间隙(EPVS)与非心源性脑梗死患者缺血性卒中复发的关系。方法:收集2019年6月~2020年12月期间住院的临床资料完整的704例急性非心源性脑梗死患者,评估患者EPVS的部位及严重程度并分组。随访1年,根据有无缺血性卒中复发分为复发组和未复发组,比较两组患者临床资料及影像学资料之间的差异,通过Logistic回归分析复发缺血性卒中的危险因素。结果:随访1年时,复发组100例(14.20%),未复发组604例(85.80%),两组在年龄、高血压、糖尿病、空腹血糖、服用抗血小板药物情况、服用他汀药物、脑动脉狭窄、基底节EPVS方面均有统计学差异(P < 0.05),Logistic回归分析显示年龄、高血压、糖尿病、脑动脉狭窄、中重度基底节EPVS是卒中复发的独立危险因素,规律服用抗血小板药物是其独立保护因素。结论:中重度基底节EPVS与复发缺血性卒中存在相关性,中重度基底节EPVS是复发性缺血性卒中的独立危险因素,可作为未来缺血性卒中复发的预测指标。Objective: To investigate the relationship between enlarged perivascular spaces (EPVS) and recur-rent ischemic stroke in patients with noncardiogenic cerebral infarction. Methods: A total of 704 patients with acute ischemic stroke admitted to our hospital from June 2019 to December 2020 were chosen in our study. Patients were evaluated by the site and severity of EPVS and followed up for 1 year. According to the recurrence of ischemic stroke, they were divided into a recurrence group and a non-recurrence group, comparing the clinical data and imaging data of the two groups. The independent influencing factors of recurrent ischemic stroke were determined by multivariate Logistic regression analysis. Results: At the one-year follow-up, 100 cases (14.20%) were in the re-currence group and 604 cases (85.80%) in the non-recurrence group. There were statistically sig-nificant differences between the two groups in age, hypertension, diabetes, fasting blood glucose, antiplatelet drugs, lipid regulating drugs, cerebral artery stenosis, and BG-EPVS. Multivariate lo-gistic regression analysis showed that age, hypertension, diabetes, cerebral artery stenosis, and BG-EPVS were independent risk factors for recurrent ischemic stroke, taking antiplatelet drugs was an independent protective factor for recurrent ischemic stroke. Conclusion: Moderate-severe BG-EPVS is associated with recurrent ischemic stroke. The moderate-severe BG-EPVS is an inde-pendent risk factor for recurrent ischemic stroke.

关 键 词：扩大的血管周围间隙 脑小血管病 复发性卒中 

分 类 号：R74[医药卫生—神经病学与精神病学]