微波消融术治疗非小细胞肺癌的近期疗效分析  

Analysis of Short-Term Efficacy of Microwave Ablation in the Treatment for Non-Small Cell Lung Cancer

作　　者：刘晓炜 孟广显 孙舸[1] 吕德胜[1] 

机构地区：[1]大连医科大学附属第二医院胸外科,辽宁 大连

出　　处：《临床医学进展》2023年第3期4638-4646,共9页Advances in Clinical Medicine

摘　　要：背景:近年来,肺癌的发病率和死亡率在全球所有恶性肿瘤中是最高的。针对早期及中期的肺癌,手术仍是临床治疗的首选,然而只有约20%~30%的患者可以进行手术。对于一般身体状况差,心肺功能欠佳,多种慢性基础疾病缠身等拥有明确手术禁忌症或出于主观恐惧以及受限于经济条件无法行手术治疗的患者来说,消融不失为一种有效的治疗方案。目的:本研究旨在对CT引导下微波消融术治疗肺恶性肿瘤的有效性及安全性进行统计和相关因素分析,并找出影响MWA近期疗效的相关因素,探究MWA治疗肺恶性肿瘤的临床规律。方法:本研究收集了2019年1月至2022年6月就诊于大连医科大学附属第二医院的50例患者的资料。所有患者均行CT引导下微波消融术。收集患者的基线资料如年龄、性别、肿瘤直径、肿瘤部位、手术时间、消融能量、肿瘤距胸膜的距离、病理类型等数据,并进行统计学分析得到结果,对统计学结果进行分析研究,最终得出结论。针对收集到的患者各项基础数据资料,应用中文版SPSS26.0软件进行处理,按照统计学规范,合理运用t检验、秩和检验、logistic回归分析等方法,检验标准为P 0.05均无统计学意义。肿瘤直径(P = 0.001),结节类型(P = 0.037),P < 0.05有统计学意义。将单因素分析有意义的因素带入有序回归分析中,得出肿瘤直径(P = 0.007),P < 0.05,具有统计学意义,且为正相关因素,即肿瘤直径越大近期疗效越差。结论:1) MWA治疗肺恶性肿瘤近期疗效确切,有效率及疾病控制率较高;2) 肿瘤直径为影响近期疗效的相关因素,肿瘤直径越大,近期疗效越差。Background: In recent years, lung cancer has had the highest incidence and mortality rate of all malignancies worldwide. For early and intermediate stage lung cancer, surgery remains the first choice of clinical treatment, yet only about 20%~30% of patients can undergo surgery. Ablation is an effective treatment option for patients who are generally in poor health, have poor cardiopul-monary function, have multiple chronic underlying diseases, have clear contraindications to sur-gery or have a perceived fear of surgery and are unable to afford it. Objective: The aim of this study was to conduct statistical and correlative factor analysis on the effectiveness and safety of CT-guided microwave ablation in the treatment of pulmonary malignancies, and to find out the relevant fac-tors affecting the recent efficacy and complications of MWA, and to investigate the clinical pattern of MWA in the treatment of pulmonary malignancies. Methods: This study collected data from 50 pa-tients who attended the Second Affiliated Hospital of Dalian Medical University from January 2019 to June 2022. All patients underwent CT-guided microwave ablation. Baseline data such as age, gender, tumour diameter, tumour site, operation time, ablation energy, distance of the tumour from the pleura, pathological type and other data were collected from the patients and statistical analysis was performed to obtain the results, and the statistical results were analysed and studied to draw the final conclusions. For the various basic data collected from the patients, the Chinese version of SPSS26.0 software was applied to process them, and t-test, rank sum test, logistic regression analy-sis were reasonably used according to statistical norms, and the test standard was P 0.05 were not statisti-cally significant. Tumour diameter (P = 0.001), nodule type (P = 0.037), P < 0.05 were statistically significant. Bringing the factors that were significant in the univariate analysis into the ordered re-gression analysis yielded a statistically significant an

关 键 词：肺恶性肿瘤 微波消融 体层摄影术 近期疗效 

分 类 号：R73[医药卫生—肿瘤]