儿童MOG抗体相关疾病的不典型临床表型  

Atypical Clinical Phenotype of MOG Antibody-Related Disease in Children

作　　者：王晓宇[1] 李秀娟[1] 

机构地区：[1]重庆医科大学附属儿童医院神经内科,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿科学重庆市重点实验室,重庆

出　　处：《临床医学进展》2023年第3期4860-4866,共7页Advances in Clinical Medicine

摘　　要：髓鞘少突胶质细胞糖蛋白免疫球蛋G抗体(MOG-IgG)相关疾病(MOGAD)典型临床表型,如急性播散性脑脊髓炎(ADEM)、视神经炎(ON)、视神经脊髓炎谱系疾病(NMOSD)、横贯性脊髓炎(TM)已被临床医生所熟知,但近年来逐渐报道了一些少见的临床表型,如皮质脑炎、孤立性癫痫发作、脑白质营养不良样表型、无菌性脑膜炎、髓鞘少突胶质细胞糖蛋白抗体相关疾病与抗N-甲基-D-天冬氨酸受体脑炎重叠综合征等,而由于这些少见临床表型在临床和影像上表现不典型,临床医生对其仍缺乏系统的认识,常常容易误诊误治或延迟诊治。为进一步提高临床医生对儿童MOGAD不典型临床表型的认识,本文对上述MOGAD的少见临床表型进行了归纳总结。The typical clinical phenotypes of myelin oligodendrocytes glycoprotein immunoglobulin egg G an-tibody (MOG-IgG) related diseases (MOGAD), such as acute disseminated encephalomyelitis (ADEM), optic neuritis (ON), neuromyelitis optica spectrum disease (NMOSD), transverse myelitis (TM), have been well known by clinicians, but in recent years, some rare clinical phenotypes, such as cerebral cortical encephalitis, isolated seizures, leukodystrophy-like phenotypes, aseptic meningitis, the overlapping syndrome of myelin oligodendrocyte glycoprotein antibody-associated disorders and anti-N-methyl-D-aspartate receptor encephalitis (MNOS), etc., have been gradually reported. Due to the atypical clinical and imaging manifestations of these rare clinical phenotypes, clinicians still lack systematic understanding of them, and are often prone to misdiagnosis, misdiagnosis or de-layed diagnosis and treatment. In order to further improve clinicians’ understanding of the atypical clinical phenotypes of MOGAD in children, this article summarizes and analyzes the rare clinical phenotypes of MOGAD mentioned above.

关 键 词：髓鞘少突胶质细胞糖蛋白抗体相关疾病(MOGAD) 不典型临床表型 儿童 

分 类 号：R74[医药卫生—神经病学与精神病学]