基质金属蛋白酶-9及其抑制剂在中枢神经系统免疫性疾病中的研究进展  

Recent Research on Matrix Metalloproteinase-9 and Its Inhibitors in Central Nervous System Immune Diseases

作　　者：周侣丽 蒋莉[2] 

机构地区：[1]重庆医科大学附属儿童医院神经内科,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆 [2]重庆医科大学附属儿童医院,国家儿童健康与疾病临床医学研究中心,儿童发育疾病研究教育部重点实验室,儿科学重庆市重点实验室,重庆

出　　处：《临床医学进展》2023年第4期5165-5169,共5页Advances in Clinical Medicine

摘　　要：中枢神经系统免疫性疾病泛指一类由免疫机制介导的神经系统疾病,其发病机制十分复杂,血脑屏障(blood-brain barrier, BBB)的破坏在其中起着重要的作用。基质金属蛋白酶(matrix metallopro-teinases, MMPs)家族可通过降解基底膜及紧密连接等成分而破坏BBB,近年来研究发现MMP-9及抑制剂组织金属蛋白酶抑制因子-1 (Tissue inhibitor of metalloproteinase-1, TIMP-1)可通过破坏BBB而参与多种中枢神经系统免疫性疾病的疾病进程,并与疾病的严重程度与预后等相关。本文就MMP-9及TIMP-1在几种中枢神经系统免疫性疾病的研究进展做一综述。Central nervous system immune diseases generally refer to kinds of nervous system diseases me-diated by immune mechanism. Their pathogenesis is very complex, and the destruction of blood- brain barrier (BBB) plays an important role in it. The matrix metalloproteinases (MMPs) family can destroy BBB by degrading basement membrane and tight junctions and other components. In re-cent years, it has been found that MMP-9 and its inhibitor tissue metalloproteinase inhibitor-1 (TIMP-1) take participate in disease process of various central nervous system immune diseases by destroying BBB. MMP-9 and TIMP-1 are related to the severity and prognosis of the disease. This article reviews research progress of MMP-9 and TIMP-1 in several central nervous system immune diseases.

关 键 词：基质金属蛋白酶-9 组织金属蛋白酶抑制因子-1 中枢神经系统免疫性疾病 

分 类 号：R73[医药卫生—肿瘤]