淋巴细胞胞浆蛋白2的功能及其在恶性肿瘤中的研究进展  

The Function of Lymphocyte Cytoplasmic Protein 2 and Its Research Progress in Malignant Tumors

作　　者：陈静[1] 张莉[1] 

机构地区：[1]新疆医科大学第一附属医院综合内四科,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第4期5494-5500,共7页Advances in Clinical Medicine

摘　　要：淋巴细胞胞浆蛋白2 (Lymphocyte cytoplasmic protein 2, LCP2,也称SLP-76)参与调控多种免疫细胞的活动,在T细胞激活中发挥着重要作用,介导T细胞生长发育过程中的多个信号转导过程,是多种疾病发展过程中的关键调节因子。其中,SLP-76可能与激活T细胞介导的抗肿瘤活性机制有关,在多种恶性肿瘤的发生和转移中发挥重要作用。本文归纳了SLP-76的结构域所参与免疫系统相关的调控机制以及对在肿瘤中的临床意义作一综述,为后续的研究提供参考。Lymphocyte cytoplasmic protein 2 (LCP2, also known as SLP-76) participates in regulating the ac-tivities of various immune cells, plays an important role in the activation of T cells, mediates multi-ple signal transduction processes in the growth and development of T cells, and is a key regulatory factor in the development of various diseases. Among them, SLP-76 may be related to the mecha-nism of activating anti-tumor activity mediated by T cells and play an important role in the occur-rence and metastasis of various malignant tumors. This article summarizes the regulatory mecha-nism of SLP-76 involved in the immune system and its clinical significance in cancer, providing a reference for future research.

关 键 词：淋巴细胞胞浆蛋白2 恶性肿瘤 免疫细胞 SLP-76 

分 类 号：R73[医药卫生—肿瘤]