外泌体中miRNA在缺血性脑卒中的研究进展  

Research Progress of Exosomes Derived miRNAs in Ischemic Stroke

作　　者：郭坤 朱博[2] 李蓉 郗静 王宁[1] 狄政莉[1] 顾乃兵[1] 

机构地区：[1]西安市中心医院神经内科,陕西 西安 [2]延安大学医学院,陕西 延安

出　　处：《临床医学进展》2023年第4期5848-5854,共7页Advances in Clinical Medicine

摘　　要：脑卒中在全球范围内发病率、致残率和致死率居于前列,对患者、家庭和社会造成了极大的压力和负担。外泌体作为一类广泛存在于人体血液和体液中的生物信息载体,携带有丰富的生物信息分子。在缺血性脑卒中的发生过程中,外泌体不仅积极参与并反映疾病的进展,而且在细胞间信息传递和免疫反应调节中发挥了至关重要的作用。近年来,随着对外泌体研究的不断深入,越来越多的证据表明脑卒中后外泌体中的miRNA在抑制神经细胞凋亡、促进血管新生和神经细胞修复等方面具有重要作用。因此,通过对外泌体携带的miRNA进行深入研究,探讨疾病发生和发展的相关机制,将有助于推动缺血性脑卒中预测、诊断和治疗方面的发展,进而提高患者的生活质量和生存率。本文旨在综述外泌体携带的miRNA在缺血性脑卒中诊断、治疗和预防方面的应用及其潜在价值,以期为未来相关领域的研究提供参考和启示。As a prevalent global health concern, stroke is characterized by high incidence, disability, and mor-tality rates, thereby imposing significant burdens on patients, families, and society at large. Exo-somes, which carry an abundance of biologically informative substances, are present in human blood and bodily fluids. In the context of ischemic stroke, exosomes not only contribute to and re-flect disease onset and progression, but also serve crucial functions in cellular information exchange and immune response modulation. Ongoing research has revealed the potential of exosome-derived miRNAs to inhibit apoptosis in nerve cells, stimulate angiogenesis, and repair damaged nerve cells. The study of exosomal miRNAs plays a vital role in elucidating the mechanisms underlying ischemic stroke and advancing the fields of prediction, diagnosis, and treatment. This review examines the applications of exosome-derived miRNAs in ischemic stroke and provides inspiration for future re-search in related fields.

关 键 词：缺血性脑卒中 外泌体miRNAs 生物靶标细胞治疗 

分 类 号：R74[医药卫生—神经病学与精神病学]