肿瘤相关巨噬细胞在非小细胞肺癌中的研究进展  

Research Progress of Tumor Associated Macrophages in Non-Small Cell Lung Cancer

作　　者：彭修法 张春玲[2] 

机构地区：[1]青岛大学医学部,山东 青岛 [2]青岛大学第二附属医院呼吸与危重症医学科,山东 青岛

出　　处：《临床医学进展》2023年第4期5855-5863,共9页Advances in Clinical Medicine

摘　　要：作为一种恶性肿瘤,肺癌是癌症相关死亡最常见原因。其主要分小细胞肺癌(small cell lung cancer, SCLC)与非小细胞肺癌(non-small cell lung cancer, NSCLC)两种类型,其中最常见亚型为NSCLC。随着对肿瘤认识的加深,新的治疗手段不仅集中于靶向肿瘤细胞本身,还逐渐认识到破坏肿瘤和其所在微环境中间质细胞之间相互作用的重要性。肿瘤相关巨噬细胞(Tumor-associated macrophages, TAMs)广泛存在于不同肿瘤的肿瘤微环境(tumor microenvironment, TME),是TME中占比最高的细胞成分。证据表明TAMs与NSCLC的发生、发展有密切的联系。因此靶向TAMs有可能成为肺癌治疗的潜在靶点。本文从肿瘤相关巨噬细胞的来源、极化、与肿瘤细胞的相互作用以及靶向肿瘤相关巨噬细胞等多个方面的研究进展进行综述。As a malignant tumor, lung cancer is the most common cause of cancer-related death, which is mainly divided into non-small cell lung cancer (NSCLC), the most common subtype and small cell lung cancer (SCLC). With the deepening understanding of tumor, besides targeting tumor cells, re-searchers gradually realize the significance of destroying the interaction between tumor and its microenvironment intermediate cells. Tumor associated macrophages (TAMs) widely exist in tumor microenvironment (TME), and are the most vital cell component in TME. Evidence shows that TAMs are closely related to the occurrence and development of NSCLC. Therefore, TAMs may become a potential target for the treatment of lung cancer. In this paper, we reviewed the progress of TAMs in the aspects of origin, polarization, interaction with NSCLC tumor cells and targeting TAMs.

关 键 词：肿瘤相关巨噬细胞 极化 非小细胞肺癌 

分 类 号：R73[医药卫生—肿瘤]