探究中性粒细胞与白蛋白比值(NAR)对肺内源性急性呼吸窘迫综合征(ARDSp)预后的预测价值  

Prognostic Value of the Neutrophil to Albumin Ratio for Predicting Mortality in Pa-tients with Acute Respiratory Distress Syn-drome Originating from Pulmonary Disease

作　　者：胡权钺 王导新[1] 

机构地区：[1]重庆医科大学附属第二医院,呼吸与危重症医学科,重庆

出　　处：《临床医学进展》2023年第4期6266-6273,共8页Advances in Clinical Medicine

摘　　要：目的:探讨中性粒细胞与白蛋白比值(NAR)对肺内源性急性呼吸窘迫综合征(ARDSp)预后的预测价值。方法:回顾性分析126例ARDSp患者的临床资料。根据28天转归情况将患者分为生存者组及非生存者组,收集一般资料、实验室检查等指标,Logistic回归分析28 d死亡的独立危险因素,受试者操作特征曲线(ROC曲线)评价预测价值。结果:纳入ARDSp患者126例,非生存者组59例,生存者组67例,28天死亡率为46.83%。非生存者组年龄、男性患者比例、血小板计数、中性粒细胞、SOFA评分、APACHEII评分、中性粒细胞与白蛋白比值高于生存者组,白蛋白低于生存者组,差异有统计学意义(P 0.323时,ARDSp患者死亡率较高。并且NAR的ROC曲线下面积大于中性粒细胞(AUC = 0.713)、白蛋白(AUC = 0.696)、APACHE II (AUC = 0.715),以及SOFA的ROC曲线下面积(AUC = 0.665)。结论:NAR对ARDSp患者28天预后有较好的预测价值,是28天死亡的独立危险因素。Objective: To investigate the prognostic value of neutrophil to albumin ratio (NAR) in patients with pulmonary endogenous acute respiratory distress syndrome (ARDSp). Methods: The clinical data of 126 patients with ARDSp were analyzed retrospectively. The patients were divided into survival group and non-survivor group according to the 28 day outcome. General data, laboratory tests and other indicators were collected. The independent risk factors of 28 day death were analyzed by lo-gistic regression, and the predictive value was evaluated by the receiver operating characteristic curve (ROC curve). Results: 126 patients with ARDSP were included, 59 in the non-survivor group and 67 in the survivor group. The 28-day mortality rate was 46.83%. The age, proportion of male patients, platelet count, neutrophil, SOFA score, APACHEII score, ratio of neutrophil to albumin in the non-survivor group were higher than those in the survivor group, and albumin was lower than that in the survivor group, with statistically significant difference (P 0.323, the mortality of patients with ARDSp was higher. The area under the ROC curve of NAR is larger than that of neutrophils (AUC = 0.713), albumin (AUC = 0.696), APACHE II (AUC = 0.715), and SOFA (AUC = 0.665). Conclusion: NAR has a good predictive value for the 28 day prognosis of ARDSp patients and is an independent risk factor for 28 day mortality.

关 键 词：肺内源性急性窘迫呼吸综合征 中性粒细胞与白蛋白比值 预后 

分 类 号：R73[医药卫生—肿瘤]