胎儿微嵌合细胞及抗原通过外泌体途径调节HLA-C影响复发性流产  

Effect of Fetal Microchimeristic Cells and Antigens on Recurrent Spontaneous Abortion by Regulating HLA-C through Exocrine Pathway

作　　者：卢冲冲 王珊[1,2] 

机构地区：[1]山东大学,山东 济南 [2]山东省立医院,山东 济南

出　　处：《临床医学进展》2023年第4期6389-6393,共5页Advances in Clinical Medicine

摘　　要：复发性流产作为妇产及生殖领域一疑难病症,主要表现为2次及以上的自然流产,其发病机制广泛而复杂。主要涉及染色体、母胎免疫等各方面原因。胚胎作为一种半同种异体移植物,其自身细胞及抗原可通过胎盘循环进入母体进而调节母体的免疫功能。外泌体作为一种直径在40~160 nm之间的囊泡,可作为运输载体包裹蛋白、非编码RNA等多种物质来实现细胞间的信号传导及物质传递。母体与胚胎免疫识别依靠HLA家族的不同亚型来实现,而HLA-C是唯一可在滋养细胞表面表达的MHC I类分子,其可作为杀伤细胞免疫球蛋白样受体的配体发挥免疫调节作用。综上所述,胎儿微嵌合细胞及抗原可通过外泌体途径调节HLA-C影响复发性流产的产生及进展。As a difficult disease in the field of gynecology, obstetrics and reproduction, recurrent spontaneous abortion is mainly manifested as two or more miscarriages, and its pathogenesis is extensive and complex. It mainly involves chromosome, maternal and fetal immunity and other reasons. Embryo, as a kind of semi-allogeneic graft, its own cells and antigens can enter the mother through the pla-centa circulation to regulate the mother’s immune function. As a kind of vesicle with a diameter of 40~160 nm, exosomes can be used as a transport carrier to wrap protein, non-coding RNA and oth-er substances to realize signal transmission and material transmission between cells. Mothers and embryos rely on different subtypes of HLA family to realize, and HLA-C is the only MHC molecule that can be expressed on the surface of trophoblasts, which can play an immunomodulatory role as a ligand of killer cell immunoglobulin-like receptor. To sum up, fetal microchimeric cells and antigens can regulate HLA-C through the exocrine pathway to affect the generation and progress of recurrent abortion.

关 键 词：复发性流产 胎儿微嵌合(FMC) 外泌体 HLA-C 

分 类 号：R73[医药卫生—肿瘤]