常见牙源性间充质干细胞及其在牙周再生的应用进展  

Common Odontogenic Mesenchymal Stem Cells and Their Application Progress in Periodontal Regeneration

作　　者：王文浩 胡高辅 王奥 吴燕岷[1] 

机构地区：[1]浙江大学医学院附属第二医院牙周科,浙江 杭州

出　　处：《临床医学进展》2023年第5期7141-7150,共10页Advances in Clinical Medicine

摘　　要：牙源性间充质干细胞是牙周组织再生工程的重要研究方向之一,主要包括DPSC、PDLSC,GMSC等。通过选择具有性能和应用优势的牙源性间充质干细胞作为种子细胞,充分发挥其诱导组织再生的能力,可在体内实现一定程度的牙周软硬组织修复效果。在牙周组织再生工程中,合适的生物医学材料常可作为载体负载牙源性间充质干细胞用于牙周炎导致的牙周支持组织缺损。本文将回顾不同牙源性间充质干细胞群体的特性及其在牙周组织再生中的应用进展。Odontogenic mesenchymal stem cell is one of the important research directions of periodontal tis-sue regeneration engineering, mainly including DPSC, PDLSC, GMSC, etc. By selecting dental mesen-chymal stem cells with performance and application advantages as seed cells and giving full play to their abilities to induce tissue regeneration, a certain degree of periodontal soft and hard tissue re-pair effect can be achieved in vivo. In periodontal tissue regeneration engineering, suitable bio-medical materials can often be used as carriers to load dental mesenchymal stem cells for perio-dontal support tissue defects caused by periodontitis. This article will review the characteristics of different dental mesenchymal stem cell populations and their application progress in periodontal tissue regeneration.

关 键 词：牙源性间充质干细胞 牙周炎 组织再生 

分 类 号：R78[医药卫生—口腔医学]