碱性磷酸酶在临床相关疾病认知障碍中的研究  

Research on Alkaline Phosphatase in Cognitive Impairment of Clinical Related Diseases

作　　者：李卓 刘冀[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院老年医学科,青海 西宁

出　　处：《临床医学进展》2023年第5期8541-8546,共6页Advances in Clinical Medicine

摘　　要：认知障碍的发病率随全球人口老龄化呈逐年升高趋势,其最严重可发展为痴呆,给个人及家庭带来了沉重的负担。碱性磷酸酶(ALP)作为人体内众多酶中的一种,发挥着强大的作用,同时它也是目前免疫诊断试剂产品最常用的标记酶之一,拥有稳定性高、灵敏度高等诸多优点。而近些年来,大量研究显示,ALP水平在认知障碍中也存在显著增高。本文就ALP的结构及生物学特性以及在临床相关性疾病认知障碍中作用的研究作一综述。The incidence of cognitive disorders increases year by year with the aging of the global population, and the most serious can develop into dementia, which brings a heavy burden to individuals and families. Alkaline phosphatase (ALP), as one of the many enzymes in human body, plays a powerful role. At the same time, ALP is also one of the most commonly used marker enzymes in immunodi-agnostic reagent products. It has many advantages, such as high stability and high sensitivity. In recent years, a large number of studies have shown that ALP level is also significantly increased in cognitive impairment. This review reviews the structure and biological characteristics of ALP and its role in cognitive impairment in clinically related diseases.

关 键 词：认知障碍 碱性磷酸酶 临床相关疾病 

分 类 号：R74[医药卫生—神经病学与精神病学]