脂蛋白a与缺血性脑卒中的研究进展  

Advanced Research on Lp(a) and Ischemic Stroke

作　　者：林洁 王爱华 

机构地区：[1]山东大学齐鲁医学院,山东 济南 [2]山东省千佛山医院神经病学科,山东 济南

出　　处：《临床医学进展》2023年第6期8966-8972,共7页Advances in Clinical Medicine

摘　　要：脑卒中是目前导致人类死亡的第二大原因,也是造成成年人残疾的主要原因,超过半数幸存者遗留不同程度的残疾。积极预防及治疗脑卒中至关重要。血脂水平升高,尤其低密度脂蛋白胆固醇(LDL-C)浓度增加已被公认为脑动脉粥样硬化与缺血性脑卒中的危险因素,但将LDL-C水平控制在指南目标值内仍存在脑卒中残余风险。脂蛋白a [Lp(a)]是一种脂质蛋白复合体,结构与低密度脂蛋白(LDL)类似,可以促进泡沫细胞形成、斑块中脂质的沉积以及血栓形成和炎症反应参与动脉粥样硬化的形成,与缺血性脑卒中的风险及预后关系密切。本文就Lp(a)的结构与作用机制、影响因素、检测方法、与缺血性卒中的关系及治疗方法进行概述。Stroke is currently the second leading cause of human death and the major cause of disability in adults, with more than half of survivors left with varying degrees of disability. Positive prevention and treatment of stroke is essential. Elevated lipid levels, especially increased concentrations of low-density lipoprotein cholesterol (LDL-C), are recognized as risk factor for cerebral atherosclerosis and ischemic stroke, but there is still a remaining risk of stroke when LDL-C levels are limited to the guideline target values. Lipoprotein (a) is a lipid protein complex with a structure similar to that of LDL that promotes foam cell formation, deposition of lipids in plaques, and thrombosis and inflam-matory responses involved in atherosclerosis, and is closely related to the risk and prognosis of is-chemic stroke. This article provides an overview of the structure and mechanism of the effects of Lp(a), factors of its impact, detection methods, relationship with ischemic stroke, and therapeutic approaches.

关 键 词：脂蛋白A 缺血性脑卒中 综述 

分 类 号：R74[医药卫生—神经病学与精神病学]