脑白质病变与内分泌因素的研究进展  

Research Progress on White Matter Lesions and Endocrine Factors

作　　者：杨雅婷 冶学兰[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院神经内科,青海 西宁

出　　处：《临床医学进展》2023年第6期9292-9300,共9页Advances in Clinical Medicine

摘　　要：脑白质病变(White matter lesions, WML)发病率高、起病隐匿、易被忽略,也是脑小血管病(Cerebral Small Vessel Disease, CSVD)最常见的一种影像学标志。近年来的研究发现内分泌功能也与脑白质病变的发生密切相关,对脑白质病变的治疗、预后、病因识别等方面具有独特的优势,内分泌功能异常是心脑血管损伤重要且可以干预的危险因素。其中,糖尿病作为脑白质病变的危险因素,其他内分泌因素包括甲状腺功能、雌激素等也可能与脑白质病变有关。本文就脑白质病变与糖尿病、甲状腺激素、雌激素等内分泌因素的联系做一综述,全面总结脑白质病变在内分泌功能方面的研究进展。The incidence rate of leukoencephalopathy is high, its onset is hidden, and it is easy to be ignored. It is also the most common imaging marker of cerebral small vessel disease (CSVD). In recent years, research has found that endocrine function is also closely related to the occurrence of white matter lesions, and has unique advantages in the treatment, prognosis, and etiology identification of white matter lesions. Abnormal endocrine function is an important and interventable risk factor for car-diovascular and cerebrovascular injury. Among them, diabetes is a risk factor for leukoencephalo-pathy, and other endocrine factors, including thyroid function, estrogen, glucocorticoid receptor polymorphism, may also be related to leukoencephalopathy. This article reviews the relationship between leukoencephalopathy and endocrine factors such as diabetes, thyroid hormone, estrogen, and comprehensively summarizes the research progress of leukoencephalopathy in endocrine.

关 键 词：脑白质病变 内分泌因素 糖尿病 甲状腺激素 雌激素 

分 类 号：R74[医药卫生—神经病学与精神病学]