MicroRNA-34家族在恶性肿瘤中的作用:从基础到临床  

Role of MicroRNA-34 Family in Malignant Tumors: From Bench to Bedside

作　　者：井文君 张雪[2] 于晓鹏 杨帅[2] 魏红梅[2] 

机构地区：[1]潍坊医学院临床医学院,山东 潍坊 [2]青岛大学附属青岛市中心医院肿瘤综合二科,山东 青岛

出　　处：《临床医学进展》2023年第6期9624-9633,共10页Advances in Clinical Medicine

摘　　要：随着分子生物学技术及临床研究的进展,发现恶性肿瘤的发生与发展与许多分子通路相关。MicroRNAs (miRNAs)是一种高度保守的单链内源性非编码RNA,它是多种恶性肿瘤中一类重要的调节因子,可以在翻译水平抑制癌基因的表达,从而抑制恶性肿瘤的产生与发展。miRNAs种类繁多,其中,microRNA-34家族(miRNA-34s)在多种恶性肿瘤的增殖、侵袭、迁移中发挥重要作用。本文将结合最新基础及临床研究,探讨miRNA-34s在乳腺癌、肝细胞癌、非小细胞肺癌、胃癌等多种肿瘤中的表达与作用,以及miRNA-34s对癌症转移相关机制——上皮间质转化(EMT)、癌症干细胞(CSCs)、程序性死亡蛋白-1 (PD-L1)的调节方式,并评估microRNA-34家族作为肿瘤治疗新靶点的潜力。With the progress of molecular biology technology and clinical research, it is found that the occur-rence and development of malignant tumors are related to many molecular pathways. MicroRNAs (miRNAs) is a highly conserved single-stranded endogenous non-coding RNA, which is an important regulator in a variety of malignancies, and can inhibit the expression of oncogenes at the transla-tional level, thus inhibiting the occurrence and development of malignancies. There are many kinds of miRNAs, among which, the microRNA-34 family (miRNA-34s) plays an important role in the pro-liferation, invasion, and migration of a variety of malignant tumors. This paper will combine the latest basic and clinical research to explore the expression and role of miRNA-34s in breast cancer, hepatocellular carcinoma, nonsmall-cell lung cancer, gastric cancer and other cancer, and miR-NA-34s to cancer metastasis related mechanism—epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), programmed cell death 1 ligand 1 (PD-L1) regulation, and evaluate the potential of microRNA-34 family as a new target in tumor treatment.

关 键 词：恶性肿瘤 MICRORNAS MiRNA-34 EMT 癌症干细胞 

分 类 号：R73[医药卫生—肿瘤]