25-羟基维生素D与各系统疾病相关性的研究进展  

Research Progress on the Correlation between 25-Hydroxyvitamin D and Diseases of Various Systems

作　　者：张岩 牛晓珊[2] 

机构地区：[1]新疆医科大学研究生学院,新疆 乌鲁木齐 [2]新疆维吾尔自治区人民医院全科医疗科,新疆 乌鲁木齐

出　　处：《临床医学进展》2023年第6期9705-9711,共7页Advances in Clinical Medicine

摘　　要：维生素D [Vitamin D VD]是一种脂溶性维生素,属于固醇类衍生物,在人体生长代谢中起着重要作用。其中最重要的是1,25-二羟基维生素D3 [1,25-(OH)2VD3],被称为活性维生素D,通过人体内的维生素D受体(VDR)介导发挥广泛生物学作用,除了作用于甲状旁腺、骨组织发挥钙磷代谢的经典效应外,其与呼吸、心血管、消化、神经精神、泌尿等系统疾病也有一定的相关性。在人体血液循环中VD的主要形式是25-羟基维生素D [25-(OH)VD],临床上常以血25-(OH)VD的含量反映人体VD水平。为引起临床医师对维生素D的重视,及时改善患者维生素D缺乏状态,现针对25-(OH)VD与各系统疾病相关性的研究进展予以综述。Vitamin D [VD] is a fat-soluble vitamin, belonging to the steroid derivatives, which plays an im-portant role in human growth and metabolism. One of the most important is 1,25-dihydroxyvitamin D3 [1,25-(OH)2VD3], known as active vitamin D, which plays a wide range of biological effects through the vitamin D receptor (VDR) in the human body. In addition to the classic effect of calcium and phosphorus metabolism in parathyroid gland and bone tissue, it is also involved in respiratory, cardiovascular, digestive, and neuropsychiatric processes. Diseases of the urinary system and other systems also have a certain correlation. The main form of VD in human blood circulation is 25-hy- droxyvitamin D [25-(OH)VD]. In clinical practice, the concentration of 25-(OH)VD in blood is often used to reflect the level of VD in human body. In order to attract the attention of clinicians to vita-min D and improve the status of vitamin D deficiency in patients in time, this article reviews the re-search progress of the correlation between 25-(OH)VD and diseases of various systems.

关 键 词：25-羟基维生素D 各系统疾病 研究进展 

分 类 号：R15[医药卫生—营养与食品卫生学]