乳腺癌骨转移相关miRNAs  

miRNAs Associated with Bone Metastases in Breast Cancer

作　　者：蔡艳秋 王淼舟[1] 

机构地区：[1]青海大学附属医院乳腺疾病诊疗中心,青海 西宁

出　　处：《临床医学进展》2023年第6期10029-10037,共9页Advances in Clinical Medicine

摘　　要：乳腺癌是女性最常见的原发性恶性肿瘤,骨转移是乳腺癌最常见的远处转移部位,骨转移会给患者造成相应的临床症状,从而使患者更加痛苦,严重影响其生活质量,尽管目前双磷酸盐等药物的使用在一定程度上可以减缓并改善骨相关症状,但是探索乳腺癌骨转移未知的机制,并且进行个体化治疗仍是很重要的,miRNA作为骨转移中细胞内分子变化的新驱动因素,正在被积极地探讨,已经有许多miRNA被证实与乳腺癌骨转移相关。Breast cancer is the most common primary malignant tumor in women, and bone metastasis is the most common distant metastasis site of breast cancer. Bone metastasis will cause corresponding clinical symptoms to patients, which will make patients more painful and seriously affect their quality of life. Although the use of bisphosphonates and other drugs can alleviate and improve bone related symptoms to a certain extent, explore the unknown mechanism of breast cancer bone me-tastasis, and individualized treatment is still very important. As a new driving factor of intracellular molecular changes in bone metastasis, miRNA is being actively discussed. Many miRNAs have been confirmed to be related to bone metastasis of breast cancer.

关 键 词：乳腺癌 骨转移 MIRNA RANKL/RANK/OPG系统 

分 类 号：R73[医药卫生—肿瘤]