Pin1与VEGF在肺癌中的表达及相关性  

The Expression and Correlation of Pin1 and VEGF in Lung Cancer

作　　者：王珊 郭丽颖 宋文广 

机构地区：[1]华北理工大学研究生学院,临床医学院,河北 唐山 [2]河北医科大学研究生学院,临床医学院,河北 石家庄 [3]唐山市工人医院,肿瘤内科,河北 唐山

出　　处：《临床医学进展》2023年第6期10075-10080,共6页Advances in Clinical Medicine

摘　　要：Pin1是一肽脯氨酰异构酶,能特异性地催化靶蛋白,细胞的正常增殖与分化,以及肿瘤的转移与生长受到蛋白质中的Ser-Pro (丝氨酸–脯氨酸)或Thr-Pro (苏氨酸–脯氨酸)的磷酸化调控。通过抑制pin1活性,从而可达到抑制肿瘤细胞生长的目的。VEGF是一种功能强大且能产生多种生物学效应的细胞因子,在创伤组织及肿瘤组织中,均可产生高表达,而高表达的VEGF更容易产生利于肿瘤生长的微环境。Pin1和VEGF在肺癌中高表达,可被用于肿瘤标志物的检测指标,或作为双靶点联合治疗肺癌的突破口,本文综述了Pin1与VEGF功能与结构,为肺癌的发生发展和治疗方法提供有利的依据,为肺癌患者的多通道联合治疗提供有力的支持。Pin1 is a peptide prolyl isomerase that can specifically catalyze target proteins. Normal cell prolif-eration and differentiation, as well as tumor metastasis and growth, is regulated by the phosphory-lation of Ser Pro (serine proline) or Thr Pro (threonine proline) in proteins. By inhibiting the activi-ty of pin1, the goal of inhibiting tumor cell growth can be achieved. VEGF is a powerful cytokine that can produce a variety of biological effects. It can be highly expressed in both traumatic and tumor tissues, and highly expressed VEGF is more likely to produce a microenvironment conducive to tu-mor growth. Pin1 and VEGF are highly expressed in lung cancer and can be used as detection indi-cators for tumor markers, or as a breakthrough point for dual target combination therapy of lung cancer. This article reviews the function and structure of Pin1 and VEGF, providing favorable basis for the occurrence, development, and treatment methods of lung cancer, and providing strong sup-port for multi-channel combination therapy of lung cancer patients.

关 键 词：肺癌 PIN1 VEGF 综述 

分 类 号：R73[医药卫生—肿瘤]