细胞分裂周期相关蛋白5的功能及其在癌症发生中作用的研究进展  

Research Progress of the Function of CDCA5 and Its Role in Cancer Progression

作　　者：范锦博 田甜 孙卓 

机构地区：[1]西安市病原微生物与肿瘤免疫重点实验室,陕西 西安 [2]西安医学院基础医学研究所,陕西 西安

出　　处：《临床医学进展》2023年第6期10153-10162,共10页Advances in Clinical Medicine

摘　　要：细胞分裂周期相关蛋白5 (CDCA5)又名Sororin,最初作为一种调控细胞周期的蛋白被发现,它在姐妹染色单体粘连、细胞周期调控、DNA损伤修复中具有重要作用。近年来CDCA5在癌症发生发展中的作用被逐渐发现,CDCA5在包括肝细胞癌、肺癌、前列腺癌、卵巢癌、膀胱癌、乳腺癌、胃癌、口腔鳞状细胞癌和食管鳞状细胞癌在内的多种癌症中具有肿瘤促进因子的作用。CDCA5参与癌症发生发展的机制主要有:AKT通路、ERK通路、细胞周期调控、蛋白互作等。CDCA5具有作为多种癌症诊断、预后分子标志物及治疗靶点的应用前景。Cell division cycle-associated protein 5 (CDCA5), also called Sororin, was first identified as a regula-tor of the cell cycle. It plays important roles in sister chromatid cohesion, cell cycle regulation and DNA damage repair. Recently it has been discovered that CDCA5 plays a part in the progression of various types of cancer, it promotes the progression of different types of cancer including hepato-cellular carcinoma, lung cancer, prostate cancer, ovarian cancer, bladder cancer, breast cancer, gas-tric cancer, oral squamous cell carcinoma and esophageal squamous cancer. CDCA5 exerts its cancer promoting functions through several mechanisms, such as the AKT pathway, ERK pathway, cell cy-cle regulation and protein interactions. CDCA5 has potential to become diagnosis/prognostic mark-er and target for treatment in many cancer types.

关 键 词：细胞分裂周期相关蛋白5 癌症 姐妹染色单体粘连 肿瘤促进因子 

分 类 号：R73[医药卫生—肿瘤]