新辅助放疗在直肠癌中的应用及研究进展  

Application and Advances of Neoadjuvant Radiotherapy in Rectal Cancer

作　　者：刘思潮 陈小娇 杨怡萍 

机构地区：[1]西安医学院研究生院,陕西 西安 [2]陕西省肿瘤医院,陕西省放疗治疗临床医学研究中心,陕西 西安

出　　处：《临床医学进展》2023年第7期10854-10862,共9页Advances in Clinical Medicine

摘　　要：直肠癌作为最常见的恶性肿瘤之一,近年来发病率及死亡率日益升高。同时,直肠癌的治疗也逐渐标准化,已经有多项研究表明术前同步放化疗联合根治性手术治疗已成为直肠癌的标准治疗方法。全世界也在为提高放化疗疗效和更好的个体化治疗而探索。本文对新辅助放疗中的放疗方案的选择、放射治疗技术、放疗后手术时间间隔、放疗不良反应以及不同放疗技术下危及器官的剂量受量等问题的最新研究进展进行了系统性的综述。以期待未来直肠癌能进行更个性化的治疗。As one of the most common malignant tumors, the incidence and mortality of rectal cancer have been increasing in recent years. At the same time, the treatment of rectal cancer has been gradually standardized, and a number of studies have shown that preoperative concurrent chemoradiother-apy combined with radical surgery has become the standard treatment of rectal cancer. The world is also exploring ways to improve the efficacy of chemoradiotherapy and better individualized treatment. In this paper, the latest research progress on the selection of radiotherapy scheme in neoadjuvant radiotherapy, radiotherapy technique, surgical interval after radiotherapy, adverse effects of radiotherapy, and dose-receiving of organs at risk under different radiotherapy tech-niques are systematically reviewed, in order to look forward to more personalized treatment of rectal cancer in the future.

关 键 词：直肠癌 新辅助放疗 放射治疗技术 放疗后手术间隔 放疗不良反应 

分 类 号：R73[医药卫生—肿瘤]