甲状腺激素与脂肪组织的进展性研究  

Progressive Study on Thyroid Hormones and Adipose Tissue

作　　者：朱蓉 范培云[2] 

机构地区：[1]青海大学临床医学院,青海 西宁 [2]青海省人民医院内分泌科,青海 西宁

出　　处：《临床医学进展》2023年第7期11685-11690,共6页Advances in Clinical Medicine

摘　　要：甲状腺激素(TH)紊乱与全身能量代谢的深刻变化有关。TH的主要靶点是产热棕色脂肪组织(BAT),它可以通过表达在棕色脂肪细胞中的甲状腺激素受体(TRs)直接刺激,也可以通过表达在下丘脑神经元中的甲状腺激素受体(TRs)间接刺激。有证据表明,甲状腺激素也可诱导白色脂肪组织褐变。在这篇综述中,我们将讨论和总结近年来TH介导棕色脂肪组织活性和白色脂肪组织褐变的潜在机制。Thyroid hormone (TH) disorder is related to profound changes in systemic energy metabolism. The main target of TH is thermogenic brown adipose tissue (BAT), which can be directly stimulated by thyroid hormone receptors (TRs) expressed in brown adipose tissue cells, or indirectly stimulated by thyroid hormone receptors (TRs) expressed in hypothalamic neurons. There is evidence that thyroid hormone can also induce browning of white adipose tissue. In this review, we will discuss and summarize the potential mechanism of TH mediated brown adipose tissue activity and white adipose tissue browning in recent years.

关 键 词：甲状腺激素 棕色脂肪(BAT) 白色脂肪(WAT) 

分 类 号：R73[医药卫生—肿瘤]