纳米刀联合DEB-TACE治疗高危部位肝细胞癌1例并文献复习  

A Case Report and Literature Review of Nanoknife Combined with DEB-TACE in the Treatment of High-Risk Site Hepatocellular Carcinoma

作　　者：赵猛 张伟[2] 张浩[2] 王振光[3] 

机构地区：[1]青岛大学医学部,山东 青岛 [2]青岛大学附属医院介入医学中心,山东 青岛 [3]青岛大学附属医院核医学科,山东 青岛

出　　处：《临床医学进展》2023年第7期11964-11969,共6页Advances in Clinical Medicine

摘　　要：肝癌起病隐匿,80%左右的患者确诊时已失去手术机会。而TACE、RFA和MWA等治疗方式因微创和临床疗效确切等优势,已经成为肝癌治疗的重要选择。然而由于热沉效应及高温对消融范围内组织的破坏无选择性,限制了热消融在临近大血管、胆管和重要器官等高危部位的肝癌治疗中的应用。本例患者经纳米刀联合DEB-TACE治疗后,短期内肿瘤控制效果良好,临近血管保存完好,提示针对高危部位肝癌,纳米刀联合DEB-TACE的综合治疗模式可能是有效和安全的新治疗方案,为高危部位肝癌治疗提供新的方向。The onset of liver cancer is hidden, and about 80% of patients have lost the opportunity for surgery when diagnosed. TACE, RFA, and MWA have become important choices for the treatment of liver cancer due to their precise clinical efficacy and minimally invasive advantages. However, due to the heat sink effect and the non selective destruction of the tissue within the ablation range by high temperature, the application of thermal ablation in the treatment of liver cancer near high-risk ar-eas such as Great vessels, bile ducts and important organs is limited. After the combination of nanoknife and DEB-TACE treatment, the tumor control effect of this patient was good in the short term, and the adjacent blood vessels are well preserved, indicating that the comprehensive treat-ment of nanoknife and DEB-TACE may be an effective new treatment plan for high-risk liver cancer, providing new ideas for the treatment of high-risk liver cancer.

关 键 词：纳米刀 载药微球 经导管肝动脉化疗栓塞 肝细胞癌 

分 类 号：R73[医药卫生—肿瘤]