免疫检查点分子在复发性流产中的研究进展  

Research Progress of Immune Checkpoint Molecules in Recurrent Spontaneous Abortion

作　　者：杨慧 王珊 

机构地区：[1]山东大学齐鲁医学院,山东 济南 [2]山东省立医院妇产科,山东 济南

出　　处：《临床医学进展》2023年第8期12952-12958,共7页Advances in Clinical Medicine

摘　　要：复发性流产近年来发病率呈升高趋势,其病因复杂,约40%~50%的患者流产没有明确病因,尚无令人满意的治疗方案,严重影响育龄期患者的身心健康,如何改善这部分患者的妊娠结局是目前生殖医学领域急需解决的一大问题。免疫检查点分子是抑制免疫效应细胞的调节分子,已在肿瘤学、免疫学等领域得到了广泛的研究。近期研究表明免疫检查点分子在母胎界面免疫耐受中起重要作用,其异常表达可能通过调节母胎界面免疫细胞功能,进而参与复发性流产的发病。本文就目前研究较深入的免疫检查点分子对复发性流产的影响及干预免疫检查点分子对复发性流产妊娠结局的影响进行综述,已期为下一步病因相关的基础研究和治疗相关的临床应用提供新的思路。The incidence of recurrent spontaneous abortion has been increasing in recent years, and its etiol-ogy is complex, about 40%~50% of patients have no clear cause of abortion, there is no satisfactory treatment plan, which seriously affects the physical and mental health of patients of childbearing age, how to improve the pregnancy outcome of these patients is a major problem that needs to be solved urgently in the field of reproductive medicine. Immune checkpoint molecules are regulatory molecules that inhibit immune effector cells and have been widely studied in oncology, immunology and other fields. Recent studies have shown that immune checkpoint molecules play an important role in maternal-fetal interface immune tolerance, and their abnormal expression may be involved in the onset of recurrent miscarriage by regulating the function of maternal-fetal interface immune cells. This article reviews the effect of immune checkpoint molecules on recurrent spontaneous abortion and the effect of intervening immune checkpoint molecules on the pregnancy outcome of recurrent spontaneous abortion, which is expected to provide new ideas for the next basic research related to etiology and clinical application related to treatment.

关 键 词：免疫检查点分子 复发性流产 细胞毒性T淋巴细胞相关蛋白4 程序性细胞死亡蛋白1 T细胞免疫球蛋白和含粘蛋白结构域的蛋白3 免疫细胞 

分 类 号：R73[医药卫生—肿瘤]