论线粒体与缺血再灌注损伤的联系及肾移植中的研究进展  

The Relationship between Mitochondria and Ischemia-Reperfusion Injury and the Research Progress in Kidney Transplantation

作　　者：雷小楠 杜春[2] 梁学海 高文胜 

机构地区：[1]西安医学院研究生院,陕西 西安 [2]陕西省人民医院泌尿外科,陕西 西安 [3]凤翔区人民医院普外科,陕西 宝鸡

出　　处：《临床医学进展》2023年第8期13221-13228,共8页Advances in Clinical Medicine

摘　　要：近年来尽管针对线粒体的研究取得了很大的进展,但对于改善缺血再灌注损伤所提供的临床治疗方式的相关研究仍未取得明显突破,缺血/再灌注损伤是肾移植术后不可避免的相关后果,影响短期和长期移植效果。而线粒体相关研究中,我们收集了这一领域的相关知识,并综合讨论了当前线粒体与缺血再灌注损伤的相关联系以及对于改善肾移植提供思路,这些策略可能为未来I/R损伤提供潜在治疗方法,以及为其他组织以及器官的缺血再灌注损伤提供潜在的思路以及治疗方式。In recent years, although great progress has been made in the research on mitochondria, there has been no significant breakthrough in the clinical treatment provided by relevant research to im-prove ischemia-reperfusion injury. Ischemia-reperfusion injury is an inevitable consequence after kidney transplantation, affecting both short- and long-term transplantation results. In the mito-chondria-related studies, we collected relevant knowledge in this field and comprehensively dis-cussed the current correlation between mitochondria and ischemia-reperfusion injury and provid-ed ideas for improving kidney transplantation. These strategies may provide potential therapies for future I/R injury. It also provides potential ideas and treatments for ischemia-reperfusion injury in other tissues and organs.

关 键 词：线粒体 缺血再灌注损伤 肾移植 ROS NS11021 MPTP 

分 类 号：R69[医药卫生—泌尿科学]