以头痛伴单侧眼外肌麻痹的非典型Miller Fisher综合征一例并文献回顾  

A Case of Atypical Miller Fisher Syndrome with Headache Accompanied by Unilateral Extraocular Muscle Paralysis and Literature Review

作　　者：侯心怡 何龙浩 胡军[2] 吕桦[2] 

机构地区：[1]西安医学院研工部,陕西 西安 [2]陕西省人民医院神经内科,陕西 西安

出　　处：《临床医学进展》2023年第9期14647-14652,共6页Advances in Clinical Medicine

摘　　要：Miller-Fisher综合征(Miller-Fisher Syndrome, MFS)是一种自身免疫介导的周围神经病,是吉兰–巴雷综合征(Guillain-Barre syndrome, GBS)中非常少见的一种类型。可于任何年龄及季节发病,一般病情在数天至数周达到高峰,发病前常有呼吸道或消化道的前驱感染病史。临床上通常表现为经典的三主征,即眼肌麻痹、共济失调、腱反射减弱或消失。本文分析了2023年04月03日就诊于陕西省人民医院神经内一科的1例以头痛伴单侧眼外肌麻痹、抗GT1a抗体IgG阳性为主要表现的非典型Miller-Fisher综合征,目的是讨论如何准确的在临床工作中识别非典型的MFS,并与之相关疾病鉴别,为临床诊疗提供指导意义。Miller-Fisher syndrome is an autoimmune mediated peripheral neuropathy, a very rare type of Guillain-Barre syndrome. The disease can occur at any age and season. The diease usually peaks within days to weeks, and it is preceded by a history of respiratory or digestive tract infection. Clin-ically, it usually presents with classic triad signs, namely ophthalmoplegia, ataxia, tendon reflex weakened or disappeared. This paper collected and analyzed a case of incomplete Miller-Fisher syndrome with headache accompanied by unilateral extraocular muscles paralysis and positive an-ti-GT1A IgG antibody, which was diagnosed and treated to the first Department of Neurology in Shaanxi Provincial People’s Hospital on April 3, 2023. The purpose of this study was to discuss how to accurately identify incomplete MFS in clinical work and distinguish with related diseases, so as to provide guidance for clinical diagnosis and treatment.

关 键 词：非典型Miller-Fisher综合征 头痛 单侧眼外肌麻痹 抗GT1a抗体IgG 

分 类 号：R74[医药卫生—神经病学与精神病学]