抗LGI1抗体相关脑炎一例病例报道并文献复习  

Antibody LGI1 Autoimmune Encephalitis: A Case Report and Literature Review

作　　者：刘悦 李翠萍[2] 田新涛[3] 张晓蒙 杨绍楠 

机构地区：[1]青岛大学附属医院神经内科,山东 青岛 [2]青岛大学附属医院重症医学科,山东 青岛 [3]青岛大学附属医院泌尿外科,山东 青岛

出　　处：《临床医学进展》2023年第10期16177-16184,共8页Advances in Clinical Medicine

摘　　要：自身免疫性脑炎是一种罕见的神经系统炎症性疾病,自2005年首次报道了N-甲基-D-天冬氨酸(NMDA)抗体脑炎后,已经描述了数量惊人的新型致病抗体。根据抗体不同,自身免疫性脑炎分为不同类型,抗富亮氨酸胶质瘤灭活1 (LGI1)抗体相关性脑炎是自身免疫性脑炎的一种亚型,以急性或亚急性认知障碍、面–臂肌张力障碍发作、癫痫、精神障碍和低钠血症为特征。我们报道了一例抗LGI1抗体相关脑炎合并桥本甲状腺炎的病例。由于自身免疫性脑炎的临床和影像学表现呈多样性,常给诊断带来挑战。在这篇文章中,我们讨论了该类自身免疫性脑炎的相关特征及其他合并疾病,提高神经科医生对该类自身免疫性脑炎的认识,对早期诊断、治疗甚至预后都具有重要意义。Autoimmune encephalitis is a rare neuroinflammatory disease, and since the first report of N- Me-thyl-D-Aspartate (NMDA) antibody encephalitis in 2005, a remarkable number of novel pathogenic antibodies have been described. Autoimmune encephalitis can be categorized into different types based on the specific antibodies involved. Anti-Leucine-Rich Glioma-Inactivated 1 (LGI1) anti-body-associated encephalitis is a subtype of autoimmune encephalitis characterized by acute or subacute cognitive impairment, faciobrachial dystonic seizures, seizures, psychiatric disturbances, and hyponatremia. In this case report, we present a case of anti-LGI1 antibody-associated encepha-litis coexisting with Hashimoto’s thyroiditis. Due to the diverse clinical and radiological presenta-tions of autoimmune encephalitis, diagnosis can be challenging. In this article, we discuss the dis-tinctive features of this subtype of autoimmune encephalitis and its comorbidities. Raising aware-ness among neurologists about this type of autoimmune encephalitis is crucial for early diagnosis, treatment, and prognosis.

关 键 词：自身免疫性脑炎 桥本甲状腺炎 LGI1 免疫治疗 

分 类 号：R74[医药卫生—神经病学与精神病学]