Gd-EOB-DTPA增强核磁与CDT1蛋白在肝细胞癌诊疗中的研究进展  

Research Progress of Gd-EOB-DTPA-Enhanced Nuclear Magnetic Resonance and CDT1 Protein in the Diagnosis and Treatment of Hepatocellular Carcinoma

作　　者：赵亚龙 温生宝[2] 

机构地区：[1]青海大学临床医学院,青海 西宁 [2]青海大学附属医院影像中心,青海 西宁

出　　处：《临床医学进展》2023年第10期16332-16338,共7页Advances in Clinical Medicine

摘　　要：肝细胞癌(hepatocellular carcinoma, HCC)具有高发病率及死亡率、预后差的临床特点。为控制不良的临床结果及改善早期诊断和治疗方法,我们必须在细胞水平上加深对肝细胞癌的了解。CDT1在肝细胞癌的发生、发展和预后方面发挥了重要作用,有望成为潜在的肝细胞癌生物标志物。本文概述了CDT1在DNA复制起始中的功能以及其在肿瘤发生和发展中的作用,着重讨论了CDT1在肝细胞癌中的表达情况。此外,还总结了Gd-EOB-DTPA增强核磁共振成像的基本原理及其在肝细胞癌诊断、分化程度和预后评估中的应用,强调了其无创性和定量分析方法。最后,我们推测了Gd-EOB-DTPA核磁共振与肝细胞癌CDT1表达的相关性:作为一种无创性手段,Gd-EOB-DTPA MR对术前预测肝细胞癌CDT1的表达具有极大的应用价值。Hepatocellular carcinoma (HCC) is characterized by high morbidity, mortality and poor prognosis. In order to control adverse clinical outcomes and improve early diagnosis and treatment, we must deepen our understanding of hepatocellular carcinoma at the cellular level. CDT1 plays an im-portant role in the occurrence, development and prognosis of hepatocellular carcinoma, and is ex-pected to become a potential biomarker of hepatocellular carcinoma. This article summarizes the function of CDT1 in the initiation of DNA replication and its role in tumorigenesis and development, with emphasis on the expression of CDT1 in hepatocellular carcinoma. In addition, the basic princi-ple of Gd-EOB-DTPA-enhanced magnetic resonance imaging and its application in the diagnosis, dif-ferentiation and prognosis of hepatocellular carcinoma were summarized, and its non- invasive and quantitative methods were emphasized. Finally, we speculated the correlation between Gd-EOB-DTPA NMR and the expression of CDT1 in hepatocellular carcinoma: as a non-inva- sive method, Gd-EOB-DTPAMR has great application value in predicting the expression of CDT1 in hepa-tocellular carcinoma before operation.

关 键 词：肝细胞癌 CDT1 GD-EOB-DTPA 磁共振成像 相关性 

分 类 号：R73[医药卫生—肿瘤]