血清分子标志物与结直肠癌肝转移的相关性研究  

Study on Correlation between Serum Molecular Markers and Liver Metastasis of Colorectal Cancer

作　　者：杨楠 赵秀峰 

机构地区：[1]牡丹江医学院第一临床医学院,黑龙江 牡丹江

出　　处：《临床医学进展》2023年第10期16692-16697,共6页Advances in Clinical Medicine

摘　　要：结直肠癌被认为是最具危险的消化道癌症,其中的发病率和比例正以惊人的速度增长,对国民身体健康构成了极大威胁。研究表明,结直肠癌的预后取决于其所属的癌症类型,而晚期结直肠癌的五年生存率甚至不足15%。结直肠癌的肝部转移(Colorectal cancer liver metastasis, CRCLM)被认为是最严重的危险,其中20%~25%的病例出现了同步发展的肝部转移。本文总结了几点对血清标志物中的分子与结直肠癌肝转移之间的作用机制及相关研究。CD10、CD133、C反应蛋白等皆与结直肠癌肝转移密切相关,还有很多分子需要我们日后的研究。Colorectal cancer is considered to be the most dangerous cancer of the digestive tract, the incidence and proportion of which are increasing at an alarming rate, for the health of the nation, it poses a great threat. Studies have shown that the prognosis of colorectal cancer depends on the type of cancer it belongs to, and the five-year survival rate for advanced colorectal cancer is even less than 15%. Colorectal cancer liver metastasis (CRCLM) is considered to be the most serious risk. In 20% to 25% of cases, synchronously developing liver metastases occur. This paper summarizes the mecha-nism of action and related study between molecules in serum markers and liver metastasis of colo-rectal cancer. CD10, CD133, C-reactive protein, etc. are closely related to liver metastasis of colorec-tal cancer, and there are many molecules that need to be studied in the future.

关 键 词：结直肠癌肝转移 CD10 CD133 C反应蛋白 白蛋白 血浆纤维蛋白原 血清IV型胶原 

分 类 号：R73[医药卫生—肿瘤]