T淋巴细胞亚群对成人社区获得性肺炎的评估价值  

Evaluation Value of T Lymphocyte Subsets of Community-Acquired Pneumonia in Adults

作　　者：王慧雯 周阮萍 孙玮 霍佳慧 童学成[1] 

机构地区：[1]常州市第三人民医院感染科,江苏 常州

出　　处：《临床医学进展》2023年第11期18486-18491,共6页Advances in Clinical Medicine

摘　　要：目的:探讨外周血T淋巴细胞对成人社区获得性肺炎(community-acquired pneumonia, CAP)评估病情严重程度及预后的检测价值。方法:回顾性收集2022年12月至2023年2月本院收治的82例社区获得性肺炎患者,按病情分为非重症组肺炎42例,重症组肺炎40例。入院时行血常规分析及T淋巴细胞亚群检测,并进行比较。结果:重症组与非重症组患者的基线资料(年龄、性别)无统计学差异意义(P > 0.05)。外周血中重症肺炎组淋巴细胞计数明显低于非重症组(P 0.05)。绘制ROC曲线,CD4+T淋巴细胞计数预测重症肺炎的ROC曲线下面积(AUC)为0.787,阈值为228个/ul,敏感度为81%,特异度为70%。结论:T淋巴细胞对CAP病情监测、治疗指导有临床意义,动态监测T淋巴细胞亚群水平变化可对评估病情的严重程度及预后有指导作用。Objective: To investigate the detection value of peripheral blood T lymphocytes in assessing the se-verity and prognosis of community-acquired pneumonia (CAP) in adults. Methods: A retrospective collection of 82 patients with community-acquired pneumonia admitted to our hospital from De-cember 2022 to February 2023. Patients were divided into 42 cases of non-severe pneumonia group and 40 cases of severe pneumonia group. Blood routine and T lymphocyte subsets were per-formed on admission and compared. Results: There was no significant difference in baseline data (age and sex) between the severe group and the non-severe group (P > 0.05). The lymphocyte count of severe pneumonia group in peripheral blood was significantly lower than that in the non-severe group (P 0.05). The ROC curve showed that the area under the ROC curve (AUC) of CD4+T lymphocyte count for predicting severe pneumonia was 0.787, the threshold was 228 cells/ul, the sensitivity was 81%, and the specificity was 70%. Conclusion: T lymphocytes have clinical significance for the monitoring and treatment guidance of CAP, and dynamic monitoring of the level of T lymphocyte subsets can guide the assessment of the severity and prognosis of the dis-ease.

关 键 词：成人社区获得性肺炎 淋巴细胞计数 T淋巴细胞亚群 

分 类 号：R73[医药卫生—肿瘤]