ALS患者延髓功能障碍的临床评估方法  

Clinical Assessment of Medullary Dysfunction in Amyotrophic Lateral Sclerosis Patients

作　　者：陈高峰[1,2] 魏钧 

机构地区：[1]三峡大学基础医学院,湖北 宜昌 [2]三峡大学第一临床医学院神经内科,湖北 宜昌

出　　处：《临床医学进展》2023年第12期20220-20226,共7页Advances in Clinical Medicine

摘　　要：肌萎缩侧索硬化症(Amyotrophic lateral sclerosis, ALS)是一种累及上、下运动神经元的神经系统变性疾病,患者多数表现为进行性四肢无力和萎缩、延髓功能麻痹和锥体束征。95%的病人通常会在发病5年之内死亡,病程进展迅速。肌萎缩侧索硬化症的患者除了躯体运动功能活动受限外,延髓功能障碍是肌萎缩侧索硬化症的一个显著特征,它影响着患者的生存和生活质量。因此,早期诊断识别出患者存在球部功能障碍,从而及早改善患者球部功能障碍所导致的生活质量下降是目前研究迫切需要解决的问题。Amyotrophic lateral sclerosis (ALS) is a degenerative neurological disease involving upper and lower motor neurons. Most patients present with progressive limb weakness and atrophy, bulbar paralysis, and pyramidal tract sign. 95% of patients usually die within five years of onset, and the disease progresses rapidly. In addition to physical motor function limitation in ALS patients, bulbar dysfunction is a prominent feature of ALS, which affects the survival and quality of life of patients. Therefore, early diagnosis and identification of patients with bulb dysfunction, so as to improve the quality of life of patients with bulb dysfunction as soon as possible is an urgent problem to be solved in current research.

关 键 词：肌萎缩侧索硬化症 延髓功能障碍 临床评估 

分 类 号：R74[医药卫生—神经病学与精神病学]