NO/cGMP通路对细胞凋亡机制的影响与抑郁症的关系综述  

A Review of the Effect of the NO/cGMP Path-way on the Mechanism of Apoptosis and Its Relationship with Depression

作　　者：吴昊 刘派 丁鑫 何磊 闫萌 陈晓梅 钱占红 

机构地区：[1]内蒙古医科大学中医学院,内蒙古 呼和浩特

出　　处：《临床医学进展》2024年第1期326-331,共6页Advances in Clinical Medicine

摘　　要：抑郁症是危害人类身体健康的主要精神疾病之一,且发病率逐年上升。现有机制无法完全解释抑郁症的所有方面。细胞凋亡是细胞的一种程序性死亡,近年大量研究证明细胞凋亡与抑郁症的关系十分密切。而NO/cGMP通路在大量研究中不仅体现了其与抑郁症的联系,还体现了其与细胞凋亡的联系。在本文中,主要对抑郁症与细胞凋亡和NO/cGMP通路的关系进行了综述,包括抑郁症与细胞凋亡的联系、细胞凋亡与NO/cGMP通路的联系、以及通路与抑郁症的联系,从而为深入了解抑郁症的发病机制以及治疗提供参考。Depression is one of the major mental disorders that jeopardize human health and its incidence is increasing every year. Existing mechanisms cannot fully explain all aspects of depression. Apoptosis is a kind of programmed cell death, and a large number of studies in recent years have proved that apoptosis is very closely related to depression. And the NO/cGMP pathway has been demonstrated in a large number of studies not only in its connection with depression, but also in its connection with apoptosis. In this paper, the relationship between depression and apoptosis and NO/cGMP pathway is reviewed, including the link between depression and apoptosis, the link between apop-tosis and NO/cGMP pathway, and the link between the pathway and depression, so as to provide reference for an in-depth understanding of the pathogenesis as well as the treatment of depression.

关 键 词：抑郁症 细胞凋亡 NO CGMP PKG 

分 类 号：R74[医药卫生—神经病学与精神病学]