化疗所致恶心呕吐的相关进展  

Progress in Chemotherapy-Induced Nausea and Vomiting

作　　者：张宇恒 李国元[2] 

机构地区：[1]青海大学研究生院,青海 西宁 [2]青海大学附属医院肿瘤内二科,青海 西宁

出　　处：《临床医学进展》2024年第1期345-350,共6页Advances in Clinical Medicine

摘　　要：化疗引起的恶心和呕吐(CINV)是化疗的严重副作用,对肿瘤患者的生活质量产生负面影响,并与化疗的致吐风险有关,因此预防和治疗CINV就显得至关重要。结合国内外关于CINV指南最新的变化,本文从CINV的病理生理学、CINV的相关止吐药物,以及中高致吐性CINV的相关止吐方案、奥氮平防治CINV的进展等方面予以综述。本文就CINV的发生机制、分型、影响因素、致吐药物分级和止吐药进行综述,并重点阐述止吐药的研究进展,旨在为肿瘤科医师提供指导。Chemotherapy-induced nausea and vomiting (CINV) is a severe side effect of chemotherapy that negatively impacts the quality of life for cancer patients and is associated with the risk of emesis. Therefore, the prevention and treatment of CINV are of paramount importance. This article reviews the latest changes in domestic and international CINV guidelines, covering the pathophysiology of CINV, relevant antiemetic drugs for CINV, as well as antiemetic regimens for moderate- to-high emetogenic CINV and the progress in using ondansetron to prevent CINV. The article provides an overview of the mechanisms, classification, influencing factors, drug grading, and antiemetic drugs for CINV, with a focus on advancements in antiemetic research, aiming to provide guidance for on-cologists.

关 键 词：CINV 止吐药 奥氮平 止吐 

分 类 号：R73[医药卫生—肿瘤]