内地西藏籍大学生非酒精性脂肪性肝病现况调查及危险因素分析  

A Cross-Sectional Investigation for Prevalence and Risk Factors of Non-Alcoholic Fatty Liver Disease in Tibetan College Students in Mainland

作　　者：周娟 毋瑞朋 王宇鹤[3] 李莉[4] 杨伟[5] 牛春燕 董鸿智[7] 

机构地区：[1]西藏民族大学附属医院内科,陕西 咸阳 [2]西藏民族大学医学院,陕西 咸阳 [3]西藏民族大学附属医院检验科,陕西 咸阳 [4]西藏民族大学附属医院超声科,陕西 咸阳 [5]西藏民族大学附属医院急诊科,陕西 咸阳 [6]南京溧水区人民医院消化内科,江苏 南京 [7]西藏民族大学附属医院中医康复科,陕西 咸阳

出　　处：《临床医学进展》2024年第2期2843-2851,共9页Advances in Clinical Medicine

摘　　要：目的:对内地西藏籍大学生的非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)现况进行调查并分析其危险因素,为高海拔地区青年人群NAFLD的进一步研究提供科学依据。方法:采用方便抽样,于2022年7月对参与调研的400名来内地求学的、西藏籍学生进行问卷调查、体格检查、腹部超声检查及血清学检查,运用SPSS 18.0软件对符合纳入标准的386名学生的相关数据进行分析总结。结果:1) 386名学生中,NAFLD 59例(15.3%),其中轻度脂肪肝51例(13.2%)、中度脂肪肝5例(1.2%),重度脂肪肝3例(0.8%),女性患病率(16.9%)高于男性(13.0%)。2) 在59名NAFLD学生中,体重正常7例(11.9%),有肥胖风险30例(50.8%),肥胖22例(37.3%)。3) NAFLD学生比非NAFLD学生的ALT [(20 ± 22.7) U/L vs (13.9 ± 22.7) U/L)]、腹围[(86.81 ± 9.29) cm vs (73.68 ± 6.79) cm]、腰臀比[(0.88 ± 0.05) vs (0.84 ± 0.06)]、BMI [(26.60 ± 3.78) kg/m2 vs (20.39 ± 2.56) kg/m2]、VAI [(1.98 ± 1.24) cm2/10cm vs (1.42 ± 0.75) cm2/10cm]均高于非NAFLD (P均2 = 25.5, P = 0.000)、男性的每周锻炼的频次(3.03 ± 1.41)也多于(t = 2.9, P 2 = 9.33, P = 0.025)。结论:1) 内地西藏籍大学生NAFLD的患病率处于国内较低、高校中较高水平;2) BMI、腹围、腰臀比和VAI的增大、ALT的升高可作为NAFLD的筛查指标;3) 久坐少动、运动量少、含糖饮料摄入多是本此次研究中女性患病率高于男性的主要危险因素。4) 非肥胖型NAFLD患病率接近肥胖型NAFLD的患病率,需引起重视。Objective: To investigate prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in inland Tibetan college students, to provide a scientific basis for further research of NAFLD in the youth population at high altitude. Methods: Convenience sampling was used to choose students. Questionnaire survey, physical examination, abdominal ultrasound examination and serological examination were conducted to 400 Tibetan students who studying in mainland in 2022 July. 386 complyed with the inclusion criteria individuals’ data were summarized and analyzed by SPSS 18.0 Software. Results: 1) 59 students (13.2%) were diagnosed as NAFLD in total 386 subjects, including, 51 mild NAFLD (13.2%), 5 moderate NAFLD (1.2%) and 3 severe NAFLD (0.8%). The prevalence of female higher (16.9%) than that of male (13.0%). 2) Among the 59 NAFLD students, 7 (11.9%) were normal weight, 30 (50.8%) were overload and 22 (37.3%) were obese. 3) The ALT [(20 ± 22.7) U/L vs (13.9 ± 22.7) U/L)], circumference of abdomen [(86.81 ± 9.29) cm vs (73.68 ± 6.79) cm], waist-to-hipratio [(0.88 ± 0.05) vs (0.84 ± 0.06)], BMI [(26.60 ± 3.78) kg/m2 vs (20.39 ± 2.56) kg/m2], VAI [(1.98 ± 1.24) cm2/10cm vs(1.42 ± 0.75) cm2/10cm] of NAFLD students were higher than non-NAFLD (P 2 = 25.5, P = 0.000), the frequency of weekly exercise of men (3.03 ± 1.41) was more than (t = 2.9, P 2 = 9.33, P = 0.025). Conclusions: 1) The preva-lence of NAFLD among Tibetan college students in the mainland is relatively lower than national average but higher than other universities in the other regions. 2) Higher ALT, BMI, WC, waist-to- hip ratio and VAI can be used as screening indicators for NAFLD. 3) Sedentary time, lack of aerobic exercise, insufficient intake of vegetables, and regular weekly intake of sugary drinks are the mate-rial cause of the higher prevalence in women than in men. 4) The incidence of non-obese NAFLD is close to that of obese NAFLD, which should be paid attention to.

关 键 词：内地西藏籍大学生 非酒精性脂肪性肝病 现况调查 危险因素 

分 类 号：R57[医药卫生—消化系统]