CXCL16与大动脉粥样硬化性脑梗死及预后的关系  

Relationship between CXCL16 and Large Atherosclerotic Cerebral Infarction and Prognosis

作　　者：崔雪晨 李奔 马爱军[1,2] 

机构地区：[1]青岛大学医学院,山东 青岛 [2]青岛大学附属医院神经内科,山东 青岛

出　　处：《临床医学进展》2024年第2期4012-4022,共11页Advances in Clinical Medicine

摘　　要：大动脉粥样硬化型脑梗死的发病率约占缺血性脑梗死的50%,近年来,一系列实验及临床数据表明,炎症反应参与了动脉粥样硬化的形成,CXCL16可能在动脉粥样硬化相关病变中发挥重要作用,然而CXCL16与大动脉粥样硬化型脑梗死及预后的相关性尚不清楚。我们旨在讨论CXCL16在大动脉粥样硬化型脑梗死中的价值。方法:纳入273例大动脉粥样硬化型脑梗死患者和198例健康对照组。将大动脉粥样硬化型脑梗死患者按出院后3个月mRS评分分为两组,血清CXCL16水平通过ELISA进行定量。结果:大动脉粥样硬化型脑梗死患者血清CXCL16水平明显升高。是大动脉粥样硬化型脑梗死的独立危险因素。mRS评分 ≥ 3分组CXCL16水平高于mRS评分 < 3分组。The incidence of large atherosclerotic cerebral infarction accounts for about 50% of ischemic cere-bral infarction. In recent years, a series of experimental and clinical data have shown that inflam-mation is involved in the formation of atherosclerosis, and CXCL16 may play an important role in athetosis-related lesions. However, the correlation between CXCL16 and atherosclerotic cerebral infarction and prognosis remains unclear. We aim to discuss the value of CXCL16 in large athero-sclerotic cerebral infarction. Methods: 273 patients with large atherosclerotic cerebral infarction and 198 healthy controls were included. Patients with large atherosclerotic cerebral infarction were divided into two groups according to mRS Score 3 months after discharge. Serum CXCL16 levels were quantified by ELISA. Results: The level of serum CXCL16 was significantly increased in patients with large atherosclerotic cerebral infarction. It is an independent risk factor for large atheroscle-rotic cerebral infarction. Groups with mRS Score ≥ 3 had higher CXCL16 levels than groups with mRS Score < 3.

关 键 词：CXCL16 动脉粥样硬化 缺血性脑卒中 

分 类 号：R74[医药卫生—神经病学与精神病学]