接受卡度尼利单抗治疗的胃腺癌并发肺肿瘤血栓性微血管病1例并文献复习  

Cadonilimab for Gastric Adenocarcinoma Complicated by Pulmonary Tumor Thrombotic Microangiopathy: A Case Report and Literature Review

作　　者：成锐琪 陈雅琪 陈剑[1] 

机构地区：[1]青岛大学附属烟台毓璜顶医院肿瘤内科,山东 烟台 [2]山东第二医科大学临床医学院,山东 潍坊

出　　处：《临床医学进展》2024年第3期840-845,共6页Advances in Clinical Medicine

摘　　要：肺肿瘤血栓性微血管病(PTTM)是一种罕见的、快速进展且致命的肿瘤相关并发症,患者通常在发病后短期内进展至死亡。目前,国内报道的病例多因呼吸系统症状首诊,发病前无明确的肿瘤病史,临床早期诊断困难,接受系统性抗肿瘤治疗后肿瘤控制稳定却仍出现PTTM的病例更鲜有报道。因此我们报道了1例在接受免疫治疗后出现肺肿瘤血栓性微血管病的胃腺癌患者,并结合相关文献对病例进行总结,为临床中对肺肿瘤血栓性微血管病的早期鉴别及诊治提供经验。Pulmonary Tumor Thrombotic Microangiopathy (PTTM) is a rare, rapidly progressive and fatal tu-mor-related complication, and patients usually progress to death within a short period of time after onset. Currently, most of the cases reported in China were first diagnosed with respiratory symp-toms without a clear history of tumor prior to the onset of the disease, which made early clinical di-agnosis difficult, and fewer cases were reported in which PTTM occurred despite stable tumor con-trol after receiving systemic antitumor therapy. Therefore, we report a case of gastric adenocarci-noma patient who developed PTTM after receiving immunotherapy, and summarize the case with relevant literature to provide experience in early identification and diagnosis of PTTM in clinical practice.

关 键 词：胃癌 肺肿瘤血栓性微血管病 血栓性微血管病 卡度尼利单抗 免疫检查点抑制剂 

分 类 号：R73[医药卫生—肿瘤]