长链非编码核苷酸膀胱癌相关转录因子1在咽部鳞状细胞癌中的研究进展  

Research Progress on lncRNA BLACAT1 in Pharyngeal Squamous Cell Carcinoma

作　　者：开日麦·艾尼瓦尔 赵辉[2] 

机构地区：[1]新疆医科大学研究生院,新疆 乌鲁木齐 [2]新疆维吾尔自治区人民医院放疗中心,新疆 乌鲁木齐

出　　处：《临床医学进展》2024年第3期928-935,共8页Advances in Clinical Medicine

摘　　要：长链非编码核苷酸(long noncoding RNA, IncRNAs)是由200多个核苷酸组成的转录本,由于缺乏开放性阅读框架从而无法编码蛋白质。然而,lncRNAs以多种方式参与基因转录及转录后的多个层面,从而调控肿瘤的发生与发展。其中,长链非编码核苷酸膀胱癌相关转录因子1 (lncRNA BLACAT1)被证实通过与miRNAs竞争性结合、参与Wnt/β-catenin信号通路和STAT3信号通路以及作用于相关蛋白和分子,从而在恶性肿瘤的发生发展过程中起重要的作用。本文中,我们将概括lncRNA BLACAT1在咽部鳞状细胞癌中的作用机制,并预测其将来有望成为咽部鳞状细胞癌的新型生物标志物和治疗靶点。Long noncoding RNAs (lncRNAs) are a class of transcripts that are longer than 200 nucleotides, and since they lack an open reading frame, they do not encode proteins. However, lncRNAs are involved in multiple aspects of gene transcription and post-transcriptional regulation, thereby influencing the oncogenesis and progression of tumors. The long non-coding RNA Bladder Cancer-Associated Transcript 1 (lncRNA BLACAT1) has been confirmed to play a crucial role in the occurrence and de-velopment of malignant tumors by competitively binding with miRNAs, participating in the Wnt/β-catenin signaling pathway and STAT3 signaling pathway, and interacting with relevant pro-teins and molecules. In this paper, we will summarize the mechanism of action of lncRNA BLACAT1 in pharyngeal squamous cell carcinoma and predict that it is expected to become a novel biomarker and therapeutic target for pharyngeal squamous cell carcinoma in the future.

关 键 词：长链非编码核苷酸(lncRNAs) 长链非编码核苷酸膀胱癌相关转录因子1 (lncRNA BLACAT1) 咽部鳞状细胞癌 生物标志物 治疗靶点 

分 类 号：R73[医药卫生—肿瘤]