miRNA-378a调控免疫反应和成骨成血管研究进展  

Progress in Research of miRNA-378a Regulating Immune Response and Osteogenic Angiogenesis

作　　者：王思凡 都曼别克·阿曼台 何惠宇[1,2] 

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院),口腔修复种植科, 新疆 乌鲁木齐 [2]新疆维吾尔自治区口腔医学研究所,新疆 乌鲁木齐

出　　处：《临床医学进展》2024年第3期1309-1316,共8页Advances in Clinical Medicine

摘　　要：近年来,微小RNA (microRNAs, miRNAs)的基因治疗成为了一个热点研究方向,通过大量细胞实验、动物实验和临床实验证明了其可行性与可拓展性,使用miRNAs调控各类干细胞分化和细胞因子已成为一个新方向。miRNAs在成骨、免疫等领域发挥广泛的生物学作用,也可作为多种疾病进展的生物学标志物和预防治疗的靶标,并在各类组织修复及炎症反应中发挥其调控作用。本文将阐述miRNAs中的miRNA-378a通过调控细胞因子和干细胞来调节免疫、成骨成血管的相关进展,以期为miRNA-378a的基础研究和临床应用总结并拓展一些思路。In recent years, gene therapy of microRNAs (miRNAs) has become a hot research direction, through a large number of cell experiments, animal experiments and clinical experiments have proved its feasibility and scalability, and the use of miRNAs to regulate various kinds of stem cell differentia-tion and cytokines has become a new direction. miRNAs Play a wide range of biological roles in os-teogenesis, immunity and other fields, and can also be used as a biological marker of various dis-ease progression and a target of preventive therapy, and play its regulatory role in various tissue repair and inflammatory response. In this paper, we will explain the progress of miRNA-378a in miRNAs in regulating immunity and osteoangiogenesis by regulating cytokines and stem cells, in order to summarize and expand some ideas for the basic research and clinical application of miR-NA-378a.

关 键 词：生物学标志物 细胞实验 微小RNA 组织修复 动物实验 细胞因子 基因治疗 临床实验 

分 类 号：R73[医药卫生—肿瘤]