补体因子H相关蛋白1在足细胞疾病中的研究进展  

Research Progress of Complement Factor H-Related Protein 1 in Podocyte Diseases

作　　者：欧云塔娜 张蕾[1] 迪丽努尔·图尔荪托合提 周洪 张莉[1] 

机构地区：[1]新疆医科大学第五附属医学院肾病科,新疆 乌鲁木齐

出　　处：《临床医学进展》2024年第3期1956-1960,共5页Advances in Clinical Medicine

摘　　要：足细胞疾病(podocytopathies)是指直接或间接的足细胞损伤导致蛋白尿的肾脏疾病。国内外许多学者发现补体系统与足细胞损伤相关,补体因子H (complement factor H, CFH)及补体因子H相关蛋白1 (complement factor H-related 1, CFHR1)是补体替代途径激活过程中起重要调节作用的血浆蛋白。CFHR1在足细胞疾病中的发病机制至今仍不清楚,目前研究发现补体替代途径所介导的炎症反应可能起到关键作用,而CFHR1是补体替代途径激活过程中重要的调节物质。本文对CFHR1在足细胞疾病中的作用进行综述,以期为相关足细胞疾疾病的诊断和治疗提供参考。Podocytopathies refer to kidney diseases that lead to proteinuria due to direct or indirect podocyte injury. Many scholars at home and abroad have found that the complement system is related to podocyte injury, and complement factor H (CFH) and complement factor H-related protein 1 (CFHR1) are plasma proteins that play an important regulatory role in the activation of the complement alternative pathway. The pathogenesis of CFHR1 in podocytopathies is still unclear. Current research has found that the inflammatory response mediated by the complement alternative pathway may play a key role, and CFHR1 is an important regulatory substance in the activation process of the complement alternative pathway. This article summarizes the role of CFHR1 in podocytopathies, aiming to provide reference value for the diagnosis and treatment of related podocyte diseases.

关 键 词：补体因子H相关蛋白 补体系统 足细胞疾病 

分 类 号：R73[医药卫生—肿瘤]